Boghosian Tanya, Patarajierapun Promporn, Glasgow Ben J, Berkowitz Carla B, Bonnet Clemence, McCannel Tara A, Barrows Brad D, Fung Simon S M
Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Washington University in St. Louis School of Medicine, St. Louis, Missouri, 63110, United States.
Am J Ophthalmol Case Rep. 2025 May 3;38:102348. doi: 10.1016/j.ajoc.2025.102348. eCollection 2025 Jun.
To report a case of invasive conjunctival squamous cell carcinoma (SCC) with anterior chamber invasion that resolved spontaneously after incisional biopsy and anterior chamber paracentesis in the absence of any treatment.
A 76-year-old man presented with a 3-month history of a recurrent mass in the right eye. Examination showed an elevated, smooth amorphous lesion at the nasal conjunctivae, adherent to the scleral surface. There was also a pseudohypopyon at the angle adjacent to the lesion. Incisional biopsy of the right conjunctival lesion and intracameral fine-needle aspiration (FNA) were performed, which confirmed recurrent invasive SCC. Brachytherapy was planned but was deferred when spontaneous regression of the lesion was noted at the interim visit. The lesion completely resolved within one year post-biopsy with no additional interventions and has remained with no signs of recurrence two years after regression, permitting uneventful cataract surgery for visual rehabilitation.
Invasive conjunctival squamous cell carcinoma is an advanced form of ocular surface neoplasia, typically necessitating extensive surgical excision and chemical or biologic therapy. This case highlights a potential pathway for the spontaneous resolution of squamous cell carcinoma post-incisional biopsy, although the precise underlying mechanisms remain unclear. Understanding these mechanisms could inform future treatment for squamous cell carcinoma and other neoplasms.
报告1例侵袭性结膜鳞状细胞癌伴前房侵犯的病例，该病例在切开活检和前房穿刺后未进行任何治疗而自行消退。
一名76岁男性，右眼反复出现肿物3个月。检查发现鼻侧结膜有一个隆起、表面光滑的无定形病变，与巩膜表面粘连。病变相邻房角处还有一个假性前房积脓。对右侧结膜病变进行了切开活检并进行了前房内细针穿刺抽吸（FNA），结果证实为复发性侵袭性鳞状细胞癌。原本计划进行近距离放射治疗，但在中期随访时发现病变自发消退，于是推迟了治疗。活检后1年内病变完全消退，未进行其他干预，消退后2年仍无复发迹象，得以顺利进行白内障手术以恢复视力。
侵袭性结膜鳞状细胞癌是眼表肿瘤的一种晚期形式，通常需要广泛的手术切除以及化学或生物治疗。本病例突出了切开活检后鳞状细胞癌自发消退的一种潜在途径，尽管确切的潜在机制尚不清楚。了解这些机制可为未来鳞状细胞癌及其他肿瘤的治疗提供参考。
