School of Health Sciences, University of Wollongong, Wollongong, NSW, 2500, Australia.
Obes Surg. 2012 Apr;22(4):536-43. doi: 10.1007/s11695-011-0573-0.
To investigate and compare food tolerance and gastrointestinal quality of life following three bariatric procedures approximately 2 to 4 years post-surgery: adjustable gastric banding (AGB), Roux-en-Y gastric bypass (RYGBP), and sleeve gastrectomy (SG). A secondary aim was to test for a relationship between food tolerance and gastrointestinal quality of life.
In this prospective cross-sectional study, participants (including pre-surgery controls) completed two questionnaires: a food tolerance questionnaire (n = 129) and a Gastrointestinal Quality of Life Index (GIQLI) (n = 119). Kruskal-Wallis and Mann-Whitney tests were performed, and significance was adjusted using a post-hoc Bonferroni correction. Spearman's rank correlation coefficients were calculated to evaluate the relationship between food tolerance and GIQLI scores.
Food tolerance: the control and SG groups produced the highest median scores (24.5 and 24.0, respectively), indicating superior food tolerance. The median score of the AGB group was significantly lower than all other groups (15.5, P < 0.001). Gastrointestinal quality of life: the SG group ranked superior, producing the highest median score (120.5), which was significantly greater than the AGB (94.0, P = 0.005) and control groups (96.0, P = 0.006). GIQLI scores correlated significantly with food tolerance scores (r = 0.522, P < 0.01). The median excess weight loss was similar in the SG and RYGBP groups (76.3% and 76.5%), with the AGB group significantly lower at 38.2%.
Food tolerance and gastrointestinal quality of life, 2 to 4 years post-surgery are ostensibly best after SG, followed closely by RYGBP. AGB appears the least effective across these parameters. A significant positive relationship between food tolerance and gastrointestinal quality of life was confirmed.
本研究旨在大约术后 2 至 4 年时，通过对比三种减重手术（可调胃束带术、胃旁路术和袖状胃切除术）后患者的食物耐受性和胃肠道生活质量，来探讨并比较这三种术式的优劣。本研究的次要目的是检验食物耐受性和胃肠道生活质量之间是否存在关联。
本前瞻性的交叉研究共纳入了 129 名参与者（包括术前对照组），这些参与者填写了食物耐受性问卷和胃肠道生活质量指数（GIQLI）问卷。采用 Kruskal-Wallis 和 Mann-Whitney 检验，并通过事后 Bonferroni 校正进行了显著性调整。采用 Spearman 秩相关系数来评估食物耐受性和 GIQLI 评分之间的关系。
食物耐受性：对照组和袖状胃切除术组的中位数评分最高（分别为 24.5 和 24.0），表明其食物耐受性较好。可调胃束带术组的中位数评分显著低于其他所有组（15.5，P<0.001）。胃肠道生活质量：袖状胃切除术组排名最高，产生的中位数评分（120.5）显著高于可调胃束带术（94.0，P=0.005）和对照组（96.0，P=0.006）。GIQLI 评分与食物耐受性评分显著相关（r=0.522，P<0.01）。袖状胃切除术和胃旁路术组的中位 excess weight loss（体重减轻百分比）相似（分别为 76.3%和 76.5%），而可调胃束带术组显著较低，为 38.2%。
大约术后 2 至 4 年时，患者的食物耐受性和胃肠道生活质量在袖状胃切除术组最佳，胃旁路术组次之，可调胃束带术组最差。证实了食物耐受性和胃肠道生活质量之间存在显著的正相关关系。
