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从大肠杆菌中分离到的含有 bla(CTX-M-1)基因的复杂 1 类整合子：一种潜在的新型耐药基因捕获工具包。

Complex class 1 integron containing bla ( CTX-M-1 ) genes isolated from Escherichia coli: a potentially novel resistant gene-capturing tool kit.

机构信息

The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

出版信息

Curr Microbiol. 2012 Mar;64(3):265-70. doi: 10.1007/s00284-011-0062-7. Epub 2011 Dec 16.

DOI:10.1007/s00284-011-0062-7
PMID:22170571
Abstract

For this study, ten complex class 1 integron was characterized in Escherichia coli (E. coli) isolates from Zhenjiang. Among the ten isolates, five included the bla ( CTX-M-1 ) gene between orf513 and the IS 3000. Analysis the five isolates by PFGE showed that zj102 and zj562 had same patterns profiles, which suggested that the spread of a specific clone contributed to a wide dissemination of a particular type of integron; the results also indicated that the complex class 1 integron might be a potentially novel resistant gene-capturing tool kit.

摘要

本研究对镇江分离的 10 株复杂 I 类整合子的大肠杆菌（E. coli）进行了研究。在这 10 株菌中，有 5 株菌 bla（CTX-M-1）基因位于 orf513 和 IS 3000 之间。对这 5 株菌进行 PFGE 分析表明，zj102 和 zj562 具有相同的图谱，这表明特定克隆的传播有助于特定类型整合子的广泛传播；结果还表明，复杂 I 类整合子可能是一种潜在的新型抗性基因捕获工具包。

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本文引用的文献

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Unusual class 1 integron configuration found in Salmonella genomic island 2 from Salmonella enterica serovar Emek.在肠沙门氏菌血清型埃姆斯的沙门氏菌基因组岛 2 中发现了不寻常的 1 类整合子结构。
Antimicrob Agents Chemother. 2010 Jan;54(1):513-6. doi: 10.1128/AAC.00895-09. Epub 2009 Nov 2.
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The clinical consequences of antimicrobial resistance.抗菌药物耐药性的临床后果。
Curr Opin Microbiol. 2009 Oct;12(5):476-81. doi: 10.1016/j.mib.2009.08.001. Epub 2009 Aug 27.
3
Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china.
来自中国镇江的细菌分离株中出现的四种新型耐药整合子基因盒情况
Curr Microbiol. 2009 Aug;59(2):113-7. doi: 10.1007/s00284-009-9405-z. Epub 2009 Apr 14.
4
Survey of extended-spectrum beta-lactamases in Escherichia coli isolates from a Portuguese hospital and characterisation of a novel class 1 integron (In60A) carrying the blaCTX-M-9 gene.葡萄牙一家医院分离的大肠杆菌中广谱β-内酰胺酶的调查以及携带blaCTX-M-9基因的新型1类整合子（In60A）的特性分析。
Int J Antimicrob Agents. 2006 Oct;28(4):320-4. doi: 10.1016/j.ijantimicag.2006.08.002. Epub 2006 Sep 7.
5
Antibiotic resistance in gram-negative bacteria: the role of gene cassettes and integrons.革兰氏阴性菌中的抗生素耐药性：基因盒与整合子的作用
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