Department of Nephrology, Selcuk University Meram School of Medicine, Konya, Turkey.
Ren Fail. 2012;34(2):155-9. doi: 10.3109/0886022X.2011.641514. Epub 2011 Dec 16.
Patients with end-stage renal disease (ESRD) have elevated serum levels of inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin (IL)-6. Systemic inflammation was found to be correlated with coronary artery disease (CAD) in this population. Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential marker to determine inflammation in cardiac and non-cardiac disorders. Data regarding NLR and its association with inflammation are lacking. We aimed to determine the relationship between NLR and inflammation in ESRD patients.
This was a cross-sectional study involving 61 ESRD patients (25 females and 36 males; mean age: 48.3 ± 14.5 years) receiving peritoneal dialysis (PD) or hemodialysis (HD) for ≥6 months in the Dialysis Unit of Selcuk University. NLR, CRP, TNF-α, and IL-6 levels were measured.
NLR, serum CRP, IL-6, and TNF-α levels were significantly higher in PD patients when compared with HD patients. ESRD patients with NLR ≥ 3.5 had significantly higher TNF-α levels when compared with patients with NLR < 3.5. In the bivariate correlation analysis, NLR was positively correlated with TNF-α in this population.
Simple calculation of NLR can predict inflammation in ESRD patients.
终末期肾病（ESRD）患者的血清炎症介质水平升高，包括 C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素（IL）-6。在该人群中发现全身炎症与冠状动脉疾病（CAD）相关。中性粒细胞与淋巴细胞比值（NLR）被引入作为确定心脏和非心脏疾病炎症的潜在标志物。关于 NLR 及其与炎症的关联的数据尚缺乏。我们旨在确定 NLR 与 ESRD 患者炎症之间的关系。
这是一项横断面研究，涉及 61 名接受腹膜透析（PD）或血液透析（HD）治疗≥6 个月的 ESRD 患者（女性 25 名，男性 36 名；平均年龄：48.3±14.5 岁），这些患者在 Selcuk 大学透析科接受治疗。测量 NLR、CRP、TNF-α 和 IL-6 水平。
与 HD 患者相比，PD 患者的 NLR、血清 CRP、IL-6 和 TNF-α 水平显著升高。与 NLR<3.5 的患者相比，NLR≥3.5 的 ESRD 患者的 TNF-α 水平显著升高。在双变量相关分析中，该人群中 NLR 与 TNF-α 呈正相关。
NLR 的简单计算可以预测 ESRD 患者的炎症。
