Department of Gastroenterology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China.
Department of Nephrology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, 421001, PR China.
BMC Nephrol. 2020 Nov 25;21(1):511. doi: 10.1186/s12882-020-02174-0.
Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been reported to be associated with inflammation in end-stage renal disease (ESRD) receiving dialysis. However, the value of NLR and PLR in non-dialysis patients with ESRD remains unclear.
Among 611 non-dialysis patients with ESRD in The First Affiliated Hospital of University of South China (2012-2018), we compared NLR and PLR in patients with high-sensitivity C-reactive protein (hs-CRP) levels of ≤3 mg/L vs. > 3 mg/L. Correlation of NLR and PLR to hs-CRP, PCT, ferritin were analyzed. Receiver operating characteristics (ROC) analysis was used for estimating sensitivity and specificity of NLR and PLR.
NLR was higher in the patients with high hs-CRP levels (> 3 mg/L), compared to patients with low hs-CRP levels (≤ 3 mg/L) [5.74 (3.54-9.01) vs. 3.96 (2.86-5.85), p < 0.0001]. Additionally, PLR was higher in high hs-CRP group than in low group [175.28 (116.67-252.26) vs. 140.65 (110.51-235.17), p = 0.022]. In the current study, NLR and PLR were both positively correlated with hs-CRP (rs = 0.377, p = 0.000 for NLR; rs = 0.161, p = 0.001 for PLR), PCT, leukocytes, neutrophils, platelets, and age. NLR or PLR with a cut-off value of 5.07 or 163.80 indicated sensitivity and specificity were 65.67 and 66.37% (AUC = 0.69) or 57.21 and 57.52% (AUC = 0.55), respectively.
NLR or PLR was positively correlated with hs-CRP in non-dialysis patients with ESRD. NLR might be better for identifying inflammation than PLR in this population.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已被报道与接受透析的终末期肾病（ESRD）患者的炎症有关。然而，非透析 ESRD 患者中 NLR 和 PLR 的价值尚不清楚。
在南华大学第一附属医院（2012-2018 年）的 611 名非透析 ESRD 患者中，我们比较了高敏 C 反应蛋白（hs-CRP）水平≤3mg/L 与>3mg/L 的患者的 NLR 和 PLR。分析 NLR 和 PLR 与 hs-CRP、降钙素原（PCT）、铁蛋白的相关性。采用受试者工作特征（ROC）分析 NLR 和 PLR 的敏感性和特异性。
hs-CRP 水平较高（>3mg/L）的患者 NLR 高于 hs-CRP 水平较低的患者（≤3mg/L）[5.74（3.54-9.01）vs. 3.96（2.86-5.85），p<0.0001]。此外，hs-CRP 较高组的 PLR 高于 hs-CRP 较低组[175.28（116.67-252.26）vs. 140.65（110.51-235.17），p=0.022]。在本研究中，NLR 和 PLR 均与 hs-CRP 呈正相关（rs=0.377，p=0.000 用于 NLR；rs=0.161，p=0.001 用于 PLR）、降钙素原、白细胞、中性粒细胞、血小板和年龄。NLR 或 PLR 的截断值为 5.07 或 163.80 时，敏感性和特异性分别为 65.67%和 66.37%（AUC=0.69）或 57.21%和 57.52%（AUC=0.55）。
非透析 ESRD 患者的 NLR 或 PLR 与 hs-CRP 呈正相关。在该人群中，NLR 可能比 PLR 更能识别炎症。
