University of Montpellier, Montpellier, France.
Emerg Infect Dis. 2011 Dec;17(12):2277-86. doi: 10.3201/eid1712.110783.
Like most emerging infectious disease viruses, HIV is also of zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collected 330 samples derived from nonhuman primate bushmeat at 3 remote forest sites. SIV prevalences were estimated by using a novel high-throughput assay that included 34 HIV and SIV antigens in a single well. Overall, 19% of nonhuman primate bushmeat was infected with SIVs, and new SIV lineages were identified. Highest SIV prevalences were seen in red-tailed guenons (25%) and Tshuapa red colobus monkeys (24%), representing the most common hunted primate species, thus increasing the likelihood for cross-species transmission. Additional studies are needed to determine whether other SIVs crossed the species barrier. With the newly developed assay, large-scale screening against many antigens is now easier and faster.
与大多数新发传染病病毒一样，HIV 也是人畜共患病的来源。为了评估在刚果民主共和国，从非人类灵长类动物到人类的感染性跨物种传播的风险，我们在 3 个偏远森林地点收集了 330 份非人类灵长类动物的野生动物肉类样本。通过使用一种新的高通量检测方法，在单个孔中包含 34 种 HIV 和 SIV 抗原，估计了 SIV 的流行率。总体而言，19%的非人类灵长类动物野生动物肉类感染了 SIV，并且鉴定了新的 SIV 谱系。红尾长尾猴（25%）和 Tshuapa 红色疣猴（24%）的 SIV 流行率最高，这两种猴子是最常见的捕猎灵长类动物，因此增加了跨物种传播的可能性。需要进一步研究来确定是否有其他 SIV 跨越了物种障碍。通过新开发的检测方法，现在可以更容易和更快地对许多抗原进行大规模筛查。
