Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 230K, 1530 3rd Avenue S, Birmingham, AL 35294-0022, USA.
Br J Nutr. 2012 Oct;108(7):1300-6. doi: 10.1017/S0007114511006726. Epub 2011 Dec 15.
α-Linolenic acid (18 : 3n-3) intake and linoleic acid (18 : 2n-6) intake have been associated with lower rates of CHD, though results have not been consistent. The relationship of these fatty acids with incident heart failure (HF) is not well established. We examined the hypothesis that women with higher intakes of 18 : 3n-3 and 18 : 2n-6 would have lower rates of HF hospitalisation and mortality. We measured 18 : 3n-3 and 18 : 2n-6 intake in 36 234 Swedish Mammography Cohort participants aged 48-83 years using FFQ and followed participants through Swedish inpatient and cause-of-death registers from 1 January 1998 until 31 December 2006. Cox models were used to calculate incidence rate ratios (RR) and 95 % CI. Because of multicollinearity, 18 : 3n-3 and 18 : 2n-6 were examined separately. Over 9 years, 596 women were hospitalised and fifty-five died due to HF. In models accounting for age and other covariates, the RR for HF comparing the top quintile of 18 : 3n-3 (median 1·50 g/d) with the bottom quintile (median 0·88 g/d) was 0·91 (95 % CI 0·71, 1·17, P(trend) = 0·41). The RR comparing the top quintile of 18 : 2n-6 (median 7·8 g/d) with the bottom quintile (median 4·6 g/d) was 1·14 (95 % CI 0·88, 1·46, P(trend) = 0·36). We did not find evidence for the interaction of 18 : 3n-3 and 18 : 2n-6 with each other or with long-chain n-3 fatty acids. In conclusion, these data do not support our hypothesis that 18 : 3n-3 and 18 : 2n-6 are associated with HF. However, these results may not be generalisable to populations with higher intakes of 18 : 3n-3.
α-亚麻酸（18:3n-3）和亚油酸（18:2n-6）的摄入量与冠心病（CHD）的发病率较低有关，但结果并不一致。这些脂肪酸与心力衰竭（HF）事件的关系尚未得到很好的证实。我们检验了这样一个假设，即摄入较高量的 18:3n-3 和 18:2n-6 的女性发生 HF 住院和死亡的风险较低。我们使用 FFQ 测量了瑞典乳腺 X 线摄影队列 36234 名年龄在 48-83 岁的参与者的 18:3n-3 和 18:2n-6 摄入量，并通过瑞典住院和死因登记册，从 1998 年 1 月 1 日至 2006 年 12 月 31 日随访参与者。使用 Cox 模型计算发病率比（RR）和 95%置信区间（CI）。由于存在多重共线性，我们分别检查了 18:3n-3 和 18:2n-6。在 9 年的时间里，有 596 名女性因 HF 住院治疗，55 人死亡。在考虑年龄和其他协变量的模型中，与 18:3n-3 摄入量最高五分位数（中位数 1.50g/d）相比，最低五分位数（中位数 0.88g/d）的 HF 比值比（RR）为 0.91（95%CI0.71，1.17，P（趋势）=0.41）。与 18:2n-6 摄入量最高五分位数（中位数 7.8g/d）相比，最低五分位数（中位数 4.6g/d）的 RR 为 1.14（95%CI0.88，1.46，P（趋势）=0.36）。我们没有发现 18:3n-3 和 18:2n-6 之间、它们与长链 n-3 脂肪酸之间存在交互作用的证据。总之，这些数据不支持我们的假设，即 18:3n-3 和 18:2n-6 与 HF 相关。然而，这些结果可能不适用于 18:3n-3 摄入量较高的人群。
