原发性膝关节骨关节炎患者血浆和滑液中碱性成纤维细胞生长因子与放射学严重程度的相关性。
Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis.
机构信息
Department of Biochemistry and Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Rama IV road, Patumwan, Bangkok, 10330, Thailand.
出版信息
Int Orthop. 2012 May;36(5):981-5. doi: 10.1007/s00264-011-1435-z. Epub 2011 Dec 16.
PURPOSE
The aim of this study was to investigate plasma and synovial fluid basic fibroblast growth factor (bFGF) levels in patients with primary knee osteoarthritis (OA) and to evaluate the correlation between bFGF levels and disease severity.
METHODS
Thirty-five patients with knee OA and 15 healthy individuals were recruited into this study. Knee OA grading was performed according to the Kellgren-Lawrence classification. bFGF concentrations in both plasma and synovial fluid were determined using enzyme-linked immunosorbent assay.
RESULTS
Plasma and synovial fluid bFGF levels in knee OA patients were significantly higher than in controls (P < 0.001). Moreover, plasma and synovial fluid bFGF concentrations were positively correlated with radiographic severity (r = 0.535, P < 0.001 and r = 0.570, P < 0.001, respectively). Further analysis revealed that there was a positive correlation between plasma and synovial fluid bFGF levels (r = 0.674, P < 0.001).
CONCLUSIONS
Plasma and synovial fluid bFGF levels were significantly increased in OA patients, and these elevated levels were positively correlated with radiographic severity. These findings indicate that bFGF levels may be a monitor of disease severity and could play an essential part in the pathophysiology of degenerative process in OA.
目的
本研究旨在探讨原发性膝骨关节炎（OA）患者血浆和滑液中碱性成纤维细胞生长因子（bFGF）的水平，并评估其与疾病严重程度的相关性。
方法
本研究纳入了 35 例膝 OA 患者和 15 名健康对照者。根据 Kellgren-Lawrence 分级对膝 OA 进行分级。采用酶联免疫吸附试验测定血浆和滑液中 bFGF 的浓度。
结果
膝 OA 患者的血浆和滑液 bFGF 水平明显高于对照组（P<0.001）。此外，血浆和滑液 bFGF 浓度与放射学严重程度呈正相关（r=0.535，P<0.001 和 r=0.570，P<0.001）。进一步分析表明，血浆和滑液 bFGF 水平之间存在正相关（r=0.674，P<0.001）。
结论
OA 患者的血浆和滑液 bFGF 水平显著升高，且这些升高的水平与放射学严重程度呈正相关。这些发现表明 bFGF 水平可能是疾病严重程度的监测指标，并可能在 OA 退行性过程的病理生理学中发挥重要作用。
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