Corti M, Villafañe M F, Bistmans A, Campitelli A, Narbaitz M, Baré P
Division of HIV/AIDS, Ramos Mejía Hospital, Argentina.
Int J STD AIDS. 2011 Dec;22(12):759-63. doi: 10.1258/ijsa.2011.011235.
Plasmablastic lymphoma (PBL) is a distinct disease entity of the diffuse large B-cell lymphoma, which often occurs in HIV-positive patients. The immunophenotype of this lymphoid neoplasm is characterized by the presence of plasma cell-associated markers VS38c and CD138 antigens and the absence of B-cell markers such as CD20 and CD45. The most frequent site of involvement is the oral cavity and the jaw, while several reports describe the development of PBL in extra-oral sites including the lymph nodes, the anal canal, the soft tissue, the skin and the gastrointestinal tract as less frequent. Epstein-Barr virus is often associated with PBL pathogenesis and the neoplastic cells contain this virus genome. Here we review the epidemiological, clinical, immunological, histopathological and virological characteristics and their prognosis and outcome in a series of five patients with diagnoses of HIV/AIDS and PBL.
浆母细胞淋巴瘤（PBL）是弥漫性大B细胞淋巴瘤的一种独特疾病实体，常发生于HIV阳性患者。这种淋巴肿瘤的免疫表型特征是存在浆细胞相关标志物VS38c和CD138抗原，且不存在B细胞标志物如CD20和CD45。最常受累部位是口腔和颌部，而一些报告描述PBL在口腔外部位如淋巴结、肛管、软组织、皮肤和胃肠道的发生频率较低。爱泼斯坦-巴尔病毒常与PBL发病机制相关，肿瘤细胞含有该病毒基因组。在此，我们回顾了一系列5例诊断为HIV/AIDS和PBL患者的流行病学、临床、免疫、组织病理学和病毒学特征及其预后和转归。
