病毒是如何诱使B细胞变成淋巴瘤的？
How do viruses trick B cells into becoming lymphomas?
作者信息
Cesarman Ethel
机构信息
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.
出版信息
Curr Opin Hematol. 2014 Jul;21(4):358-68. doi: 10.1097/MOH.0000000000000060.
PURPOSE OF REVIEW
Since the discovery of Epstein-Barr virus in Burkitt's lymphoma 50 years ago, only one other virus, namely Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8, has been confirmed to be a direct cause of B-cell lymphoma. Here we will review the evidence for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus as causal lymphoma agents.
RECENT FINDINGS
A deeper understanding of specific mechanisms by which Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus cause B-cell lymphomas has been acquired over the past years, in particular with respect to viral protein interactions with host cell pathways, and microRNA functions. Specific therapies based on knowledge of viral functions are beginning to be evaluated, mostly in preclinical models.
SUMMARY
Understanding the causal associations of specific infectious agents with certain B-cell lymphomas has allowed more accurate diagnosis and classification. A deeper knowledge of the specific mechanisms of transformation is essential to begin assessing whether virus-targeted treatment modalities may be used in the future.
综述目的
自50年前在伯基特淋巴瘤中发现爱泼斯坦-巴尔病毒以来，仅另一种病毒，即卡波西肉瘤相关疱疹病毒/人疱疹病毒8，被证实是B细胞淋巴瘤的直接病因。在此，我们将综述支持爱泼斯坦-巴尔病毒和卡波西肉瘤相关疱疹病毒作为淋巴瘤致病因子的证据。
最新发现
在过去几年中，人们对爱泼斯坦-巴尔病毒和卡波西肉瘤相关疱疹病毒导致B细胞淋巴瘤的具体机制有了更深入的了解，特别是在病毒蛋白与宿主细胞途径的相互作用以及微小RNA功能方面。基于病毒功能知识的特异性疗法已开始进行评估，主要是在临床前模型中。
总结
了解特定感染因子与某些B细胞淋巴瘤的因果关联有助于更准确的诊断和分类。深入了解转化的具体机制对于开始评估未来是否可使用针对病毒的治疗方式至关重要。
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