光动力疗法联合玻璃体内注射雷珠单抗治疗渗出性年龄相关性黄斑变性的一年结果
One-year results of photodynamic therapy combined with intravitreal ranibizumab for exudative age-related macular degeneration.
作者信息
Nakamura Tomoko, Miyakoshi Akio, Fujita Kazuya, Yunoki Tatsuya, Mitarai Keiichi, Yanagisawa Shuichiro, Fuchizawa Chiharu, Hayashi Atsushi
机构信息
Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
出版信息
J Ophthalmol. 2012;2012:154659. doi: 10.1155/2012/154659. Epub 2011 Dec 7.
Purpose. To evaluate the effects of photodynamic therapy (PDT) combined with intravitreal injection of ranibizumab (IVR) for exudative age-related macular degeneration (AMD). Methods. Retrospective case series. Thirty eight eyes of 38 patients with exudative AMD underwent combined therapy consisting first of IVR, followed by PDT within a week and the second IVR at 1 month. All patients were followed up for more than 12 months. The best corrected visual acuity (BCVA) and central macular thickness (CMT) were examined. Results. The mean number of IVR and PDT sessions were 2.9 ± 1.3 and 1.1 ± 0.3, respectively. The mean BCVA and CMT were significantly improved to 0.38 logMAR units (P < 0.01) and 240 μm (P < 0.01) at 12 months, respectively. Thirty-six of 38 eyes (94.8%) improved or maintained BCVA at 12 months. Conclusion. PDT combined with IVR for exudative AMD was effective at improving visual acuity and CMT with a low recurrence rate for 12 months.
目的。评估光动力疗法（PDT）联合玻璃体内注射雷珠单抗（IVR）治疗渗出性年龄相关性黄斑变性（AMD）的效果。方法。回顾性病例系列研究。38例渗出性AMD患者的38只眼接受了联合治疗，首先进行IVR，然后在一周内进行PDT，1个月时进行第二次IVR。所有患者均随访超过12个月。检查最佳矫正视力（BCVA）和中心黄斑厚度（CMT）。结果。IVR和PDT的平均治疗次数分别为2.9±1.3次和1.1±0.3次。12个月时，平均BCVA和CMT分别显著改善至0.38 logMAR单位（P<0.01）和240μm（P<0.01）。38只眼中有36只眼（94.8%）在12个月时视力提高或维持。结论。PDT联合IVR治疗渗出性AMD在提高视力和CMT方面有效，且12个月复发率低。
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