miRNAs 和 EBV BARTs 在 NPC 中的作用。
The role of miRNAs and EBV BARTs in NPC.
机构信息
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
出版信息
Semin Cancer Biol. 2012 Apr;22(2):166-72. doi: 10.1016/j.semcancer.2011.12.001. Epub 2011 Dec 10.
Abstract
The BamHI A rightward transcripts are a set of alternatively splicing transcripts produced by Epstein-Barr Virus that are highly expressed in nasopharyngeal carcinoma. These transcripts contain several open reading frames as well as precursors for twenty-two miRNAs. Although the putative proteins corresponding to these open reading frames have not been detected, several studies have identified properties that are interesting and potentially significant with respect to cellular transformation. The miRNAs, however, are very abundant in all nasopharyngeal carcinomas and several potentially significant functions have been identified for some of the miRNAs. This article will focus on the nature of this complicated set of transcripts and the evidence that they contribute to the development of nasopharyngeal carcinoma.
摘要
BamHI A 右向转录物是一组由 Epstein-Barr 病毒产生的选择性剪接转录物，在鼻咽癌中高度表达。这些转录物包含几个开放阅读框以及 22 个 miRNA 的前体。尽管尚未检测到与这些开放阅读框相对应的假定蛋白，但已有几项研究确定了与细胞转化有关的有趣且潜在重要的特性。然而，miRNA 在所有鼻咽癌中都非常丰富，并且已经确定了一些 miRNA 的一些潜在重要功能。本文将重点介绍这组复杂转录物的性质，以及它们有助于鼻咽癌发展的证据。
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本文引用的文献
1
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries.深度测序小 RNA cDNA 文库中 miRNA 代表的 RNA 连接酶依赖性偏倚。
RNA. 2011 Sep;17(9):1697-712. doi: 10.1261/rna.2799511. Epub 2011 Jul 20.
2
Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs.鼻咽癌中 Epstein-Barr 病毒编码 microRNAs 的分析揭示了潜在的生物标志物和致癌 miRNA。
Cancer. 2012 Feb 1;118(3):698-710. doi: 10.1002/cncr.26309. Epub 2011 Jun 30.
3
cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression.顺式作用对 RNA 加工和 Drosha 切割的影响可防止 Epstein-Barr 病毒潜伏 III BHRF1 表达。
J Virol. 2011 Sep;85(17):8929-39. doi: 10.1128/JVI.00336-11. Epub 2011 Jun 22.
4
The role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines.启动子甲基化在 Epstein-Barr 病毒 (EBV) 微 RNA 表达中的作用在 EBV 感染的 B 细胞系中。
Exp Mol Med. 2011 Jul 30;43(7):401-10. doi: 10.3858/emm.2011.43.7.044.
5
Notch signalling in solid tumours: a little bit of everything but not all the time.实体瘤中的 Notch 信号通路：并非无时无刻都在发挥作用，但也并非微不足道。
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6
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Virology. 2011 Apr 10;412(2):392-400. doi: 10.1016/j.virol.2011.01.028. Epub 2011 Feb 18.
7
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8
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9
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Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20370-5. doi: 10.1073/pnas.1014194107. Epub 2010 Nov 8.
10
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