顺式作用对 RNA 加工和 Drosha 切割的影响可防止 Epstein-Barr 病毒潜伏 III BHRF1 表达。
cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression.
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
J Virol. 2011 Sep;85(17):8929-39. doi: 10.1128/JVI.00336-11. Epub 2011 Jun 22.
Abstract
In Epstein-Barr virus (EBV) latency III (LTIII) infection, BHRF1 encodes three microRNAs (miRNAs). Herein we report that Drosha cleavage of LTIII BHRF1 RNA and cis-acting splicing effects inhibit splicing and inhibit BHRF1 RNA and protein expression. Evidence shown here supports the view that Drosha cleavage to generate mature miRNAs and cis-acting sequences that prevent mRNA maturation are independent processes that prevent LTIII BHRF1 expression in lymphoblastoid cell lines.
摘要
在 Epstein-Barr 病毒（EBV）潜伏 III（LTIII）感染中，BHRF1 编码三个 microRNAs（miRNAs）。本文报道，LTIII BHRF1 RNA 的 Drosha 切割和顺式作用剪接效应抑制剪接，并抑制 BHRF1 RNA 和蛋白表达。本文提供的证据支持这样一种观点，即 Drosha 切割生成成熟 miRNA 和阻止 mRNA 成熟的顺式作用序列是两个独立的过程，它们阻止了淋巴母细胞系中 LTIII BHRF1 的表达。
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