Kawecka-Jaszcz K
I Kliniki Kardiologii IK AM w Krakowie.
Przegl Lek. 1990;47(4):379-84.
In 80 subjects, aged 19-28 years with elevated blood pressure 10 years earlier, compared with a group of normotensives (n = 69) family history of hypertension and the results of echocardiography, dynamic exercise stress testing and cold pressor test were evaluated. Pathogenic role of family history was shown by the diagnosis of arterial hypertension in 84% of the parents of children and adolescents with initially elevated blood pressure. The effects of elevated blood pressure on its further course are confirmed by the incidence of borderline hypertension in 26.3% of the studied group as compared with 5.8% of the controls. The patients with elevated blood pressure were characterized by hyperkinetic cardiac state manifested by a significantly higher heart rate, higher ejection fraction and cardiac output. The results of bicycle exercise test and cold pressor tet proved useless in the prognosis. However, despite the lack of prognostic value it was found that in studied population an exercise induced rise of systolic blood pressure correlated with echocardiographic parameters of cardiac size and mass. Similarly a positive correlation was found between the highest blood pressure during exercise and left ventricular mass in patients with borderline hypertension. The studies showed prognostic difficulties in the early stage of primary hypertension emphasizing the usefulness of modern methods providing an insight into the state of labile at that age cardiovascular system.
在80名10年前血压升高、年龄在19 - 28岁的受试者中,与一组血压正常者(n = 69)相比,对高血压家族史以及超声心动图、动态运动应激试验和冷加压试验的结果进行了评估。在最初血压升高的儿童和青少年的父母中,84%被诊断为动脉高血压,这表明了家族史的致病作用。研究组中26.3%出现临界高血压,而对照组为5.8%,这证实了血压升高对其进一步发展过程的影响。血压升高的患者表现为心脏高动力状态,其特征为心率显著更高、射血分数和心输出量更高。自行车运动试验和冷加压试验的结果在预后方面并无用处。然而,尽管缺乏预后价值,但研究发现,在所研究的人群中,运动诱发的收缩压升高与心脏大小和质量的超声心动图参数相关。同样,在临界高血压患者中,运动期间的最高血压与左心室质量之间也发现了正相关。研究表明,原发性高血压早期存在预后困难,强调了现代方法对于深入了解该年龄段不稳定心血管系统状态的有用性。