感染痢疾志贺氏菌1型的巨噬细胞中志贺毒素的免疫标记
Immunolabelling of Shiga toxin in macrophages infected with Shigella dysenteriae 1.
作者信息
Dacosta B, Sansonetti P, Ryter A
机构信息
Unité de Microscopie Electronique, Institut Pasteur, Paris.
出版信息
Res Microbiol. 1990 Jun;141(5):543-9. doi: 10.1016/0923-2508(90)90018-l.
PMID:2218059
Abstract
Immunolabelling of Shiga toxin in macrophages infected with a non-invasive Shigella dysenteriae 1 isolate showed that bacteria remained alive for 3 h after ingestion within the phagocytic vacuole and synthesized Shiga toxin. The normal process of toxin secretion was, however, impaired by the phagosomal environment and toxin molecules accumulated within the bacterial cytoplasm.
摘要
对感染非侵袭性痢疾志贺氏菌1型分离株的巨噬细胞中志贺毒素进行免疫标记显示，细菌在吞噬泡内被摄取后存活3小时并合成志贺毒素。然而，毒素分泌的正常过程受到吞噬体环境的损害，毒素分子在细菌细胞质内积累。
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