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多囊卵巢综合征 2011 年:基因、衰老与多囊卵巢综合征睡眠呼吸暂停。

Polycystic ovary syndrome in 2011: Genes, aging and sleep apnea in polycystic ovary syndrome.

机构信息

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15-745, Chicago, IL 60611, USA.

出版信息

Nat Rev Endocrinol. 2011 Dec 20;8(2):72-4. doi: 10.1038/nrendo.2011.227.

DOI:10.1038/nrendo.2011.227
PMID:22183129
Abstract

Polycystic ovary syndrome (PCOS) is a complex genetic disease that affects approximately 7% of women of reproductive age worldwide. From novel pathways implicated in the etiology of PCOS through genome-wide association to characterization of the reproductive and metabolic changes that occur in ageing women with PCOS, the year 2011 has seen a number of studies published that highlight the intricacies of this condition.

摘要

多囊卵巢综合征(PCOS)是一种复杂的遗传性疾病,影响着全球大约 7%的育龄期女性。从与 PCOS 病因相关的新途径到对患有 PCOS 的老年女性发生的生殖和代谢变化的特征描述,2011 年发表了许多研究,突出了这种病症的复杂性。

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Nat Rev Endocrinol. 2011 Dec 20;8(2):72-4. doi: 10.1038/nrendo.2011.227.
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Causal evidence of the relationship between polycystic ovary syndrome and obstructive sleep apnea in European and East Asian populations: a two-sample Mendelian randomization study.欧洲和东亚人群中多囊卵巢综合征与阻塞性睡眠呼吸暂停之间关系的因果证据:一项两样本孟德尔随机化研究
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Polycystic ovary syndrome and its multidimensional impacts on women's mental health: A narrative review.多囊卵巢综合征及其对女性心理健康的多维影响:叙事性综述。
Medicine (Baltimore). 2024 Jun 21;103(25):e38647. doi: 10.1097/MD.0000000000038647.
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Obesity and hyperandrogenism are implicated with anxiety, depression and food cravings in women with polycystic ovary syndrome.

本文引用的文献

1
Reproductive hormone levels and anthropometry in postmenopausal women with polycystic ovary syndrome (PCOS): a 21-year follow-up study of women diagnosed with PCOS around 50 years ago and their age-matched controls.绝经后多囊卵巢综合征(PCOS)妇女的生殖激素水平和人体测量学:21 年前诊断为 PCOS 的妇女及其年龄匹配对照者的 21 年随访研究。
J Clin Endocrinol Metab. 2011 Jul;96(7):2178-85. doi: 10.1210/jc.2010-2959. Epub 2011 Apr 20.
2
Unfavorable hormonal, metabolic, and inflammatory alterations persist after menopause in women with PCOS.患有多囊卵巢综合征(PCOS)的女性在绝经后仍存在不利的激素、代谢和炎症改变。
J Clin Endocrinol Metab. 2011 Jun;96(6):1827-34. doi: 10.1210/jc.2011-0039. Epub 2011 Mar 30.
3
肥胖和高雄激素血症与多囊卵巢综合征妇女的焦虑、抑郁和食物渴望有关。
Endocrine. 2023 Oct;82(1):201-208. doi: 10.1007/s12020-023-03436-1. Epub 2023 Jun 30.
4
Prevalence of Polycystic Ovarian Syndrome in India: A Systematic Review and Meta-Analysis.印度多囊卵巢综合征的患病率:一项系统评价与荟萃分析。
Cureus. 2022 Dec 9;14(12):e32351. doi: 10.7759/cureus.32351. eCollection 2022 Dec.
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Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis.多囊卵巢综合征在 2 型糖尿病患者中的流行情况:系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2022 Aug 31;13:980405. doi: 10.3389/fendo.2022.980405. eCollection 2022.
6
Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model.姜黄素可改善多囊卵巢综合征模型大鼠的卵泡发生、性激素、凋亡标志物基因表达和抗氧化酶水平。
Vet Med Sci. 2023 Jan;9(1):290-300. doi: 10.1002/vms3.958. Epub 2022 Sep 14.
7
Polycystic Ovary Syndrome: A Brain Disorder Characterized by Eating Problems Originating during Puberty and Adolescence.多囊卵巢综合征:一种源于青春期和青少年时期的进食问题的脑部疾病。
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Clin Endocrinol (Oxf). 2017 May;86(5):739-746. doi: 10.1111/cen.13310. Epub 2017 Mar 9.
Hyperandrogenism in women with polycystic ovary syndrome persists after menopause.
多囊卵巢综合征妇女的高雄激素血症在绝经后仍持续存在。
J Clin Endocrinol Metab. 2011 Mar;96(3):623-31. doi: 10.1210/jc.2010-0130. Epub 2010 Dec 22.
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J Clin Endocrinol Metab. 2011 Feb;96(2):365-74. doi: 10.1210/jc.2010-1187. Epub 2010 Dec 1.
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Finding the missing heritability of complex diseases.寻找复杂疾病中缺失的遗传力。
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.全基因组关联数据的荟萃分析及大规模重复研究确定了2型糖尿病的其他易感基因座。
Nat Genet. 2008 May;40(5):638-45. doi: 10.1038/ng.120. Epub 2008 Mar 30.
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Genome-wide significance for dense SNP and resequencing data.全基因组范围内对于密集单核苷酸多态性(SNP)和重测序数据的显著性
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Genome-wide association studies for common diseases and complex traits.常见疾病和复杂性状的全基因组关联研究。
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