Bababeygy Simon R, Quiros Peter A
Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, DVRC 311, Los Angeles, CA 90033, USA.
Int Ophthalmol. 2011 Dec;31(6):493-5. doi: 10.1007/s10792-011-9482-4. Epub 2011 Dec 20.
The objective of the study is to report the first case of isolated trochlear palsy secondary to Lyme neuroborreliosis in an adult. A 22-year-old male presented with history of flu-like illness and headache, accompanied by vertical binocular diplopia, worse on downgaze and better in upgaze and right head tilt. Physical examination revealed trochlear palsy on the left side with a compensatory head tilt to the opposite side. A subsequent workup for trochlear palsy was conducted, including hematological and cerebral spinal fluid serum studies, and magnetic resonance imaging of the brain. Immunoglobulin (Ig)M and IgG antibodies against Borrelia burgdorferi were positive in serum and cerebral spinal fluid (CSF). Symptoms of double vision completely resolved after 3 weeks of antibiotic treatment with intravenous ceftriaxone. CSF studies, in addition to clinical symptoms of vertical double vision and a positive Parks 3-step test, are a good diagnostic tool for B. burgdorferi. Resolution of symptoms was noted after a complete course of intravenous ceftriaxone.
该研究的目的是报告首例成人因莱姆病神经疏螺旋体病继发孤立性滑车神经麻痹的病例。一名22岁男性患者有流感样疾病和头痛病史,伴有垂直性双眼复视,向下注视时加重,向上注视和向右侧头部倾斜时减轻。体格检查发现左侧滑车神经麻痹,伴有向对侧的代偿性头部倾斜。随后对滑车神经麻痹进行了一系列检查,包括血液学和脑脊液血清学检查以及脑部磁共振成像。血清和脑脊液中抗伯氏疏螺旋体的免疫球蛋白(Ig)M和IgG抗体呈阳性。静脉注射头孢曲松进行3周抗生素治疗后,复视症状完全消失。除了垂直性复视的临床症状和阳性的帕克斯三步试验外,脑脊液检查是诊断伯氏疏螺旋体的良好诊断工具。静脉注射头孢曲松一个完整疗程后症状得到缓解。