Suppr超能文献

PKM2: a gatekeeper between growth and survival.

作者信息

Harris Isaac, McCracken Susan, Mak Tak Wah

机构信息

The Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Toronto, ON M5C 2M9, Canada.

出版信息

Cell Res. 2012 Mar;22(3):447-9. doi: 10.1038/cr.2011.203. Epub 2011 Dec 20.

Abstract
摘要

相似文献

1
PKM2: a gatekeeper between growth and survival.
Cell Res. 2012 Mar;22(3):447-9. doi: 10.1038/cr.2011.203. Epub 2011 Dec 20.
2
PKM2 contributes to cancer metabolism.
Cancer Lett. 2015 Jan 28;356(2 Pt A):184-91. doi: 10.1016/j.canlet.2014.01.031. Epub 2014 Feb 4.
3
SAICAR binding activates PKM2 protein kinase activity.
Cancer Discov. 2014 May;4(5):OF20. doi: 10.1158/2159-8290.CD-RW2014-062. Epub 2014 Mar 20.
4
PKM2, cancer metabolism, and the road ahead.
EMBO Rep. 2016 Dec;17(12):1721-1730. doi: 10.15252/embr.201643300. Epub 2016 Nov 17.
5
6
Structural basis of PKM2 regulation.
Protein Cell. 2015 Apr;6(4):238-40. doi: 10.1007/s13238-015-0146-4.
7
Emerging roles of PKM2 in cell metabolism and cancer progression.
Trends Endocrinol Metab. 2012 Nov;23(11):560-6. doi: 10.1016/j.tem.2012.06.010. Epub 2012 Jul 21.
9
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics.
Cancer Lett. 2021 Apr 10;503:240-248. doi: 10.1016/j.canlet.2020.11.018. Epub 2020 Nov 24.
10
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Acta Pharmacol Sin. 2019 Apr;40(4):530-538. doi: 10.1038/s41401-018-0015-9. Epub 2018 Jun 20.

引用本文的文献

1
The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma.
PeerJ. 2025 Apr 2;13:e19213. doi: 10.7717/peerj.19213. eCollection 2025.
2
Non-metabolic enzyme function of pyruvate kinase M2 in breast cancer.
Front Oncol. 2024 Oct 1;14:1450325. doi: 10.3389/fonc.2024.1450325. eCollection 2024.
4
[RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2].
Nan Fang Yi Ke Da Xue Xue Bao. 2024 Jan 20;44(1):9-16. doi: 10.12122/j.issn.1673-4254.2024.01.02.
5
Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro.
J Mol Med (Berl). 2023 Feb;101(1-2):151-169. doi: 10.1007/s00109-022-02280-6. Epub 2023 Jan 12.
6
The roles of glycolysis in osteosarcoma.
Front Pharmacol. 2022 Aug 17;13:950886. doi: 10.3389/fphar.2022.950886. eCollection 2022.
7
Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics.
Mol Ther. 2022 Mar 2;30(3):1018-1035. doi: 10.1016/j.ymthe.2021.11.010. Epub 2021 Nov 15.
8
Hexokinase Is Required for Sex Pheromone Biosynthesis in .
Insects. 2021 Sep 30;12(10):889. doi: 10.3390/insects12100889.
9
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Oncogene. 2021 Jun;40(23):3974-3988. doi: 10.1038/s41388-021-01815-4. Epub 2021 May 14.
10
PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition.
Anal Cell Pathol (Amst). 2020 Nov 25;2020:8396023. doi: 10.1155/2020/8396023. eCollection 2020.

本文引用的文献

1
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Nature. 2011 Dec 1;480(7375):118-22. doi: 10.1038/nature10598.
2
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Science. 2011 Dec 2;334(6060):1278-83. doi: 10.1126/science.1211485. Epub 2011 Nov 3.
4
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Cell. 2011 May 27;145(5):732-44. doi: 10.1016/j.cell.2011.03.054.
5
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34. doi: 10.1073/pnas.1014769108. Epub 2011 Feb 15.
6
Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cells.
Biochem Biophys Res Commun. 2011 Jan 7;404(1):428-33. doi: 10.1016/j.bbrc.2010.11.138. Epub 2010 Dec 3.
7
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
Nature. 2010 Jan 21;463(7279):364-8. doi: 10.1038/nature08697. Epub 2009 Dec 13.
8
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431.
9
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.
J Cell Biochem. 2009 May 15;107(2):293-302. doi: 10.1002/jcb.22125.
10

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验