Kang Min-Hee, Park Hee-Myung
BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 143-701, South Korea.
J Vet Med Sci. 2012 May;74(5):645-9. doi: 10.1292/jvms.11-0483. Epub 2011 Dec 15.
A 5-year-old female Chihuahua was presented for acute collapse. Laboratory examinations showed markedly elevated levels of hepatobiliary enzymes. Empiric antibiotic therapy for bacterial infection of the liver was ineffective. The clinical signs worsened with the development of hyponatremia with hypoosmolality and elevated urine sodium levels. The dog was suspected of having acute cholangiohepatitis associated with an immune-mediated disease. Subsequently, it was diagnosed with syndrome of inappropriate antidiuretic hormone secretion (SIADH) on the basis of the specific disease criteria. Further tests showed normal function of the adrenal and thyroid glands, and MRI and cerebrospinal fluid (CSF) analysis did not show any intracranial diseases. Immunosuppressive therapy and water restriction resolved the clinical signs and improved the SIADH in this dog. This case indicates that SIADH can occur concurrently with suspected immune-mediated liver disease in dogs.
一只5岁雌性吉娃娃犬因急性虚脱前来就诊。实验室检查显示肝胆酶水平显著升高。针对肝脏细菌感染的经验性抗生素治疗无效。随着低钠血症伴低渗透压和尿钠水平升高的出现，临床症状恶化。该犬被怀疑患有与免疫介导性疾病相关的急性胆管肝炎。随后，根据特定疾病标准诊断为抗利尿激素分泌不当综合征（SIADH）。进一步检查显示肾上腺和甲状腺功能正常，MRI和脑脊液（CSF）分析未显示任何颅内疾病。免疫抑制治疗和限水缓解了该犬的临床症状并改善了SIADH。该病例表明SIADH可与犬疑似免疫介导性肝病同时发生。
