Internal Medicine Ward, Division of Rheumatology, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.
Rheumatol Int. 2012 Dec;32(12):3799-805. doi: 10.1007/s00296-011-2282-3. Epub 2011 Dec 21.
To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was measured. There was correlation between serum anti-CCP and DAS28-ESR. (R (2) = 0.71, P value < 0.01). New disease activity index was developed by replacing anti-CCP with ESR in DAS28-ESR. There was correlation between new model and DAS28-ESR. (R (2) = 0.91, P value < 0.01) The new composite index best cut-off values corresponding to DAS28-ESR values of 2.6, 3.2, and 5.1 were 3.21, 3.38, and 4.74, respectively. There was agreement between new model and DAS28-ESR for determination of patients in different disease activity categories. (Kappa = 0.71, P value < 0.01). The new disease activity index that applies serum anti-CCP may predict disease activity in RA.
为了明确血清抗环瓜氨酸肽抗体（抗-CCP）与疾病活动度之间的关系，并在类风湿关节炎（RA）中构建一个新的疾病活动指数，纳入了 105 例 RA 患者。根据 DAS28-ESR 和血清抗-CCP 评估疾病活动度。血清抗-CCP 与 DAS28-ESR 之间存在相关性（R（2）= 0.71，P 值<0.01）。通过用 ESR 替代 DAS28-ESR 中的抗-CCP 来建立新的疾病活动指数。新模型与 DAS28-ESR 之间存在相关性（R（2）= 0.91，P 值<0.01）。与 DAS28-ESR 值为 2.6、3.2 和 5.1 相对应的新综合指数最佳截断值分别为 3.21、3.38 和 4.74。新模型与 DAS28-ESR 在确定不同疾病活动度类别的患者方面具有一致性（Kappa = 0.71，P 值<0.01）。应用血清抗-CCP 的新疾病活动指数可能有助于预测 RA 的疾病活动度。
