Kaiser Elmar, Thomann Philipp A, Essig Marco, Schröder Johannes
Section of Geriatric Psychiatry, INF 280, Heidelberg, Germany.
Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):393-401. doi: 10.1159/000333082. Epub 2011 Nov 16.
Recent studies consistently reported Alzheimer's disease (AD) and, to a lower extent, mild cognitive impairment (MCI) to be accompanied by reduced cerebrospinal fluid (CSF) levels of β-amyloid. However, how these changes are related to brain morphological alterations is so far only partly understood.
CSF levels of β-amyloid (1-42) were examined with respect to cerebral atrophy in 23 subjects with MCI, 16 patients with mild-to-moderateAlzheimer's disease (AD) and 15 age-matched controls by using magnetic resonance imaging and voxel-based morphometry (VBM).
When contrasted with the controls, β-amyloid (1-42) levels were significantly lower (p < 0.05) in patients with MCI and even more so in the AD patients. This effect was significantly associated with reduced gray matter densities in both the right and left hippocampal head based on the results of a VBM analysis across the entire sample.
Our finding confirms the results of previous studies and suggests that both the decrease in β-amyloid (1-42) and the development of hippocampal atrophy coincide in the disease process.
近期研究一致报道，阿尔茨海默病（AD）以及程度较轻的轻度认知障碍（MCI）都伴有脑脊液（CSF）中β-淀粉样蛋白水平降低。然而，目前对于这些变化与脑形态学改变之间的关系仅部分得到了解。
通过磁共振成像和基于体素的形态测量法（VBM），对23名轻度认知障碍（MCI）受试者、16名轻度至中度阿尔茨海默病（AD）患者以及15名年龄匹配的对照者的脑脊液β-淀粉样蛋白（1-42）水平与脑萎缩情况进行了检测。
与对照组相比，MCI患者的β-淀粉样蛋白（1-42）水平显著降低（p < 0.05），AD患者的降低更为明显。基于对整个样本的VBM分析结果，这种效应与左右海马头部灰质密度降低显著相关。
我们的研究结果证实了先前研究的结果，并表明在疾病进程中，β-淀粉样蛋白（1-42）的减少与海马萎缩的发展是同时出现的。
