在日本脓疱疮患儿中，以II型SCCmec的PVL阴性CC89耐甲氧西林金黄色葡萄球菌为主的传播情况。
Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmec Type II in Children with Impetigo in Japan.
作者信息
Kikuta H, Shibata M, Nakata S, Yamanaka T, Sakata H, Akizawa K, Kobayashi K
机构信息
Pediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, Japan.
出版信息
Int J Pediatr. 2011;2011:143872. doi: 10.1155/2011/143872. Epub 2011 Dec 7.
Abstract
Background. The ratio of CA-MRSA in children with impetigo has been increasing in Japan. Methods. Antimicrobial susceptibilities of 136 S. aureus isolates from children with impetigo were studied. Furthermore, molecular epidemiological analysis and virulence gene analysis were performed. Results. Of the 136 S. aureus isolates, 122 (89.7%) were MSSA and 14 (10.3%) were MRSA. Of the 14 MRSA strains, 11 belonged to CC89 (ST89, ST91, and ST2117) and carried diverse types of SCCmec: type II (IIb: 3 strains; unknown subtype: 4 strains), type IVa (2 strains), and unknown type (2 strains). The remaining three strains exhibited CC8 (ST-8)-SCCmec type VIa, CC121 (ST121)-SCCmec type V, and CC5 (ST5)-nontypeable SCCmec element, respectively. None were lukS-PV-lukF-PV gene positive. Gentamicin- and clarithromycin-resistant strains were frequently found in both MRSA and MSSA. Conclusions. PVL-negative CC89-SCCmec type II strains are the most predominant strains among the CA-MRSA strains circulating in the community in Japan.
摘要
背景。在日本，脓疱疮患儿中社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）的比例一直在上升。方法。对136株从脓疱疮患儿中分离出的金黄色葡萄球菌进行了药敏试验。此外，还进行了分子流行病学分析和毒力基因分析。结果。在136株金黄色葡萄球菌分离株中，122株（89.7%）为甲氧西林敏感金黄色葡萄球菌（MSSA），14株（10.3%）为耐甲氧西林金黄色葡萄球菌（MRSA）。在14株MRSA菌株中，11株属于CC89（ST89、ST91和ST2117），携带多种类型的葡萄球菌盒式染色体mec（SCCmec）：II型（IIb：3株；未知亚型：4株）、IVa型（2株）和未知类型（2株）。其余三株分别表现为CC8（ST-8）-SCCmec VIa型、CC121（ST121）-SCCmec V型和CC5（ST5）-不可分型的SCCmec元件。均无杀白细胞素S-PV-杀白细胞素F-PV基因阳性。庆大霉素和克拉霉素耐药菌株在MRSA和MSSA中均常见。结论。PVL阴性的CC89-SCCmec II型菌株是日本社区中流行的CA-MRSA菌株中最主要的菌株。
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