Department of Oncology, Zekai Tahir Burak Women's Health Research and Education Hospital, Tunali Hilmi Cad. Binnaz Sok. No:1/5 Kavaklidere, Ankara, Turkey.
Arch Gynecol Obstet. 2011 Jan;283(1):97-101. doi: 10.1007/s00404-010-1653-4. Epub 2010 Aug 29.
Extra-mammary Paget disease is one of the rare neoplastic conditions of the skin. The most common site of involvement is the vulva and presents itself with erythematous plaques. Surgery is the most important treatment option. In the recent years, there are publications of the topical use of imiquimod cream in extra-mammary cutaneous Paget disease. We report the case of a woman with recurrent vulvar Paget disease, who underwent successful treatment with imiquimod cream. We also review the reports of other patients with vulvar Paget disease who were treated with topical imiquimod cream.
A 65-year-old woman presented to the Oncology Outpatient Clinic with an itchy lesion in her vulva for 2 years. In the gynecologic examination, a hyperkeratotic erythematous lesion was found starting from the right labium to involve clitoris, with a size of 4 × 3 cm. Pathology result was reported as Paget disease. She was operated and wide vulvar excision was performed with a safety margin of 2 cm. Then recurrence two times occurred. Because she refused surgery, imiquimod cream 5% was applied for treatment.
Imiquimod cream is an effective and safe therapeutic agent for both primary and recurring vulvar Paget disease.
乳房外 Paget 病是一种罕见的皮肤肿瘤性疾病。最常见的受累部位是外阴，表现为红斑性斑块。手术是最重要的治疗选择。近年来，有关于咪喹莫特乳膏治疗乳房外皮肤 Paget 病的报道。我们报告了一例复发性外阴 Paget 病女性患者，成功接受咪喹莫特乳膏治疗的病例。我们还回顾了其他接受局部咪喹莫特乳膏治疗的外阴 Paget 病患者的报告。
一名 65 岁女性因外阴瘙痒性皮损 2 年来肿瘤门诊就诊。妇科检查发现右侧阴唇至阴蒂有角化性红斑性皮损，大小为 4×3cm。病理结果报告为 Paget 病。她接受了手术治疗，进行了广泛的外阴切除术，安全切缘为 2cm。随后出现两次复发。由于她拒绝手术，给予咪喹莫特乳膏 5%治疗。
咪喹莫特乳膏是治疗原发性和复发性外阴 Paget 病的有效且安全的治疗药物。
