• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics.RNA干扰介导的α-烯醇化酶敲低增加了肿瘤细胞对抗微管蛋白化疗药物的敏感性。
Int J Biochem Mol Biol. 2011;2(4):303-8. Epub 2011 Oct 21.
2
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.对微管蛋白类化疗药物的敏感性受 MCL1 和 FBW7 的调控。
Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779.
3
Taxol in combination with doxorubicin or etoposide. Possible antagonism in vitro.紫杉醇与阿霉素或依托泊苷联合使用。体外可能存在拮抗作用。
Cancer. 1993 Nov 1;72(9):2705-11. doi: 10.1002/1097-0142(19931101)72:9<2705::aid-cncr2820720930>3.0.co;2-k.
4
Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.敲低Merm1/Wbscr22可减弱H460非小细胞肺癌细胞对SN-38和5-氟尿嘧啶的敏感性，而不会改变p53的表达水平。
Mol Med Rep. 2015 Jan;11(1):295-302. doi: 10.3892/mmr.2014.2764. Epub 2014 Oct 24.
5
[Impact of cyclin-dependent kinase inhibitor p27 on resistance of ovarian cancer multicellular spheroids to taxol].细胞周期蛋白依赖性激酶抑制剂p27对卵巢癌多细胞球体紫杉醇耐药性的影响
Zhonghua Yi Xue Za Zhi. 2003 Jan 10;83(1):37-41.
6
Gamma Tocopherol Reduced Chemotherapeutic-Induced ROS in an Ovarian Granulosa Cell Line, But Not in Breast Cancer Cell Lines In Vitro.γ-生育三烯酚可降低体外培养的卵巢颗粒细胞系中化疗诱导产生的活性氧，但对乳腺癌细胞系无效。
Antioxidants (Basel). 2020 Jan 7;9(1):51. doi: 10.3390/antiox9010051.
7
Therapeutic interactions between stathmin inhibition and chemotherapeutic agents in prostate cancer.在前列腺癌中，抑制Stathmin与化疗药物之间的治疗性相互作用。
Mol Cancer Ther. 2006 Dec;5(12):3248-57. doi: 10.1158/1535-7163.MCT-06-0227.
8
Enhancement by recombinant human interferon alfa of the reversal of multidrug resistance by MRK-16 monoclonal antibody.重组人干扰素α增强MRK - 16单克隆抗体对多药耐药性的逆转作用。
J Natl Cancer Inst. 1995 Jan 18;87(2):94-104. doi: 10.1093/jnci/87.2.94.
9
Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics-induced neuropathic pain.CXCL12表达的表观遗传上调介导抗微管蛋白化疗药物诱导的神经性疼痛。
Pain. 2017 Apr;158(4):637-648. doi: 10.1097/j.pain.0000000000000805.
10
Effect of Chemotherapeutics and Tocopherols on MCF-7 Breast Adenocarcinoma and KGN Ovarian Carcinoma Cell Lines .化疗药物和生育酚对 MCF-7 乳腺癌腺癌细胞系和 KGN 卵巢癌细胞系的影响。
Biomed Res Int. 2019 Jan 15;2019:6146972. doi: 10.1155/2019/6146972. eCollection 2019.

引用本文的文献

1
Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression.丝氨酸419的肿瘤特异性磷酸化在三阴性乳腺癌进展中驱动α-烯醇化酶（ENO1）的核输出。
Cell Biosci. 2024 Jun 7;14(1):74. doi: 10.1186/s13578-024-01249-x.
2
Oncogenic Alterations of Metabolism Associated with Resistance to Chemotherapy.与化疗耐药相关的代谢致癌改变。
Curr Mol Med. 2024;24(7):856-866. doi: 10.2174/1566524023666230622104625.
3
ENO1 and Cancer.烯醇化酶1与癌症
Mol Ther Oncolytics. 2022 Jan 3;24:288-298. doi: 10.1016/j.omto.2021.12.026. eCollection 2022 Mar 17.
4
Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target.α-烯醇化酶：新兴的肿瘤相关抗原、癌症生物标志物及肿瘤治疗靶点。
Front Genet. 2021 Jan 28;11:614726. doi: 10.3389/fgene.2020.614726. eCollection 2020.
5
Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.核烯醇化酶-1/髓母细胞瘤相关蛋白-1在上皮性卵巢癌中的表达及其与Wnt信号通路的关联
Transl Oncol. 2021 Jan;14(1):100910. doi: 10.1016/j.tranon.2020.100910. Epub 2020 Oct 14.
6
High-throughput, microscope-based sorting to dissect cellular heterogeneity.基于高通量显微镜的分选技术以解析细胞异质性。
Mol Syst Biol. 2020 Jun;16(6):e9442. doi: 10.15252/msb.20209442.
7
ENO1 silencing impaires hypoxia-induced gemcitabine chemoresistance associated with redox modulation in pancreatic cancer cells.ENO1基因沉默会损害胰腺癌细胞中与氧化还原调节相关的缺氧诱导吉西他滨化疗耐药性。
Am J Transl Res. 2019 Jul 15;11(7):4470-4480. eCollection 2019.
8
Chemotherapy Resistance in Advanced Ovarian Cancer Patients.晚期卵巢癌患者的化疗耐药性
Biomark Cancer. 2019 Jul 5;11:1179299X19860815. doi: 10.1177/1179299X19860815. eCollection 2019.
9
Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners.胰腺癌的新一代免疫疗法：DNA疫苗接种正在寻找新的联合伙伴。
Cancers (Basel). 2018 Feb 16;10(2):51. doi: 10.3390/cancers10020051.
10
Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis.α-烯醇化酶（ENO1）控制αv/β3整合素的表达，并调节胰腺癌的黏附、侵袭和转移。
J Hematol Oncol. 2017 Jan 13;10(1):16. doi: 10.1186/s13045-016-0385-8.

本文引用的文献

1
Regulation of cancer cell metabolism.癌细胞代谢的调控。
Nat Rev Cancer. 2011 Feb;11(2):85-95. doi: 10.1038/nrc2981.
2
P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil.P-糖蛋白（ABCB1）调节多药耐药细胞系对维拉帕米的旁系敏感性。
Arch Biochem Biophys. 2009 Nov;491(1-2):53-60. doi: 10.1016/j.abb.2009.09.012. Epub 2009 Sep 20.
3
Multifaceted roles of glycolytic enzymes.糖酵解酶的多方面作用。
Trends Biochem Sci. 2005 Mar;30(3):142-50. doi: 10.1016/j.tibs.2005.01.005.
4
A role for survivin in chemoresistance of endothelial cells mediated by VEGF.存活素在血管内皮生长因子介导的内皮细胞化疗耐药中的作用。
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4349-54. doi: 10.1073/pnas.072586399. Epub 2002 Mar 26.
5
Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches.抗血管生成药物获得性耐药的可能机制：对联合治疗方法应用的启示
Cancer Metastasis Rev. 2001;20(1-2):79-86. doi: 10.1023/a:1013172910858.
6
Multifunctional alpha-enolase: its role in diseases.多功能α-烯醇化酶：其在疾病中的作用。
Cell Mol Life Sci. 2001 Jun;58(7):902-20. doi: 10.1007/pl00000910.
7
VEGF: an update on biological and therapeutic aspects.血管内皮生长因子：生物学与治疗学方面的最新进展
Curr Opin Biotechnol. 2000 Dec;11(6):617-24. doi: 10.1016/s0958-1669(00)00153-1.
8
The glycolytic enzyme enolase is present in sperm tail and displays nucleotide-dependent association with microtubules.
Eur J Cell Biol. 2000 Feb;79(2):104-11. doi: 10.1078/S0171-9335(04)70012-6.
9
Pyruvate kinase as a microtubule destabilizing factor in vitro.
Biochem Biophys Res Commun. 1999 Jan 19;254(2):430-5. doi: 10.1006/bbrc.1998.9957.
10
Endothelial cell hypoxic stress proteins.内皮细胞缺氧应激蛋白
J Lab Clin Med. 1998 Dec;132(6):456-63. doi: 10.1016/s0022-2143(98)90122-6.

RNA干扰介导的α-烯醇化酶敲低增加了肿瘤细胞对抗微管蛋白化疗药物的敏感性。

RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics.

作者信息

Georges Elias, Bonneau Anne-Marie, Prinos Panagiotis

出版信息

Int J Biochem Mol Biol. 2011;2(4):303-8. Epub 2011 Oct 21.

PMID:22187664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3242425/
Abstract

The over-expression of α-enolase was demonstrated in several cancers, including lung, brain, breast, colon and prostate. In this report, we investigated the effects of α-enolase knockdown on the sensitivity of cancer cells to chemotherapeutic drugs. RNAi-mediated knockdown of α-enolase in A549 and H460 lung, MCF7 breast and CaOV3 ovarian cancer cells caused a significant increase in the sensitivity of these cells to antitubulin chemotherapeutics (e.g., vincristine and taxol), but not to doxorubicin, etoposide or cisplatinum. This is the first demonstration showing the effects of α-enolase expression on the sensitivity of tumor cells to clinically relevant chemotherapeutics.

摘要

α-烯醇化酶在包括肺癌、脑癌、乳腺癌、结肠癌和前列腺癌在内的多种癌症中均有过表达。在本报告中，我们研究了敲低α-烯醇化酶对癌细胞对化疗药物敏感性的影响。RNA干扰介导的A549和H460肺癌细胞、MCF7乳腺癌细胞以及CaOV3卵巢癌细胞中α-烯醇化酶的敲低，导致这些细胞对抗微管化疗药物（如长春新碱和紫杉醇）的敏感性显著增加，但对阿霉素、依托泊苷或顺铂则无此效果。这是首次证明α-烯醇化酶表达对肿瘤细胞对临床相关化疗药物敏感性的影响。