Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Canada.
Can Respir J. 2011 Nov-Dec;18(6):e89-94. doi: 10.1155/2011/290261.
BACKGROUND⁄
Knowledge of the effects of domestic endotoxin on children's lung function is limited. The association between domestic endotoxin and asthma or wheeze and lung function among school-age children (six to 18 years of age) was examined. The interaction between endotoxin and other personal and environmental characteristics and lung function was also assessed.
A case-control study was conducted in and around the rural community of Humboldt, Saskatchewan, between 2005 and 2007. Parents of cases reported either doctor-diagnosed asthma or wheeze in the previous year. Controls were randomly selected from those not reporting these conditions. Data were collected by questionnaire to ascertain symptoms and conditions, while spirometry was used to measure lung function including forced vital capacity and forced expiratory volume in 1 s. Dust collected from the child's play area floor and the child's mattress was used to quantify endotoxin, and saliva was collected to quantify cotinine levels and assess tobacco smoke exposure.
There were 102 cases and 207 controls included in the present study. Lower forced expiratory volume in 1 s was associated with higher mattress endotoxin load among female cases (beta=-0.25, SE=0.07 [P<0.01]). There was a trend toward lower forced vital capacity, which was associated with higher play area endotoxin load among cases with high tobacco smoke exposure (beta=-0.17, SE=0.09 [P<0.10]).
Findings indicated that high endotoxin levels present in common household areas of rural children with asthma or wheeze may also affect their lung function. These associations may be potentiated by tobacco smoke exposure and female sex.
关于内毒素对儿童肺功能影响的知识有限。本研究旨在调查儿童（6 至 18 岁）家中内毒素与哮喘或喘息以及肺功能之间的关联，并评估内毒素与其他个人和环境特征与肺功能之间的相互作用。
2005 年至 2007 年期间，在萨斯喀彻温省洪堡的农村社区及其周边地区进行了病例对照研究。病例组的父母报告其子女在过去一年中被诊断患有哮喘或喘息。对照组则是从没有报告这些疾病的人群中随机选择的。通过问卷调查收集症状和疾病数据，同时使用肺活量计测量肺功能，包括用力肺活量和 1 秒用力呼气量。从儿童游乐区地板和儿童床垫上收集灰尘以定量内毒素，从唾液中收集可替宁水平以评估烟草烟雾暴露。
本研究纳入了 102 例病例和 207 例对照。在女性病例中，较高的床垫内毒素负荷与较低的 1 秒用力呼气量相关（β=-0.25，SE=0.07 [P<0.01]）。有较高烟草烟雾暴露的病例中，较高的游乐区内毒素负荷与较低的用力肺活量呈趋势相关（β=-0.17，SE=0.09 [P<0.10]）。
这些发现表明，农村地区哮喘或喘息儿童家中常见区域内的高内毒素水平可能也会影响他们的肺功能。这些关联可能会受到烟草烟雾暴露和女性性别因素的影响。
