多层 DNA 折纸包装在六边形和混合晶格上。
Multilayer DNA origami packed on hexagonal and hybrid lattices.
机构信息
Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
J Am Chem Soc. 2012 Jan 25;134(3):1770-4. doi: 10.1021/ja209719k. Epub 2012 Jan 13.
Abstract
"Scaffolded DNA origami" has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher resolution of spatial addressing than has been shown previously. We also demonstrate hybrid multilayer DNA origami with honeycomb-lattice, square-lattice, and hexagonal-lattice packing of helices all in one design. The availability of hexagonal close-packing of helices extends our ability to build complex structures using DNA nanotechnology.
摘要
“有支架的 DNA 折纸术”已被证明是一种构建具有高复杂度的二维或三维物体的强大且高效的方法。多层 DNA 折纸术已通过沿着蜂巢晶格几何形状或正方形晶格几何形状包装的螺旋得到证明。在这里，我们报告了成功折叠具有在密堆积六边形晶格上排列的螺旋的多层 DNA 折纸术。这种排列方式产生了比以前显示的更高的螺旋包装密度，因此具有更高的空间寻址分辨率。我们还展示了混合多层 DNA 折纸术，其中螺旋的蜂巢晶格、正方形晶格和六边形晶格的包装都在一个设计中。螺旋的六边形密堆积的可用性扩展了我们使用 DNA 纳米技术构建复杂结构的能力。
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