调节神经性贪食症的饱腹感：胆囊收缩素的作用。
Regulating satiety in bulimia nervosa: the role of cholecystokinin.
机构信息
Psychiatric/Mental Health Department, Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts, USA.
出版信息
Perspect Psychiatr Care. 2012 Jan;48(1):34-40. doi: 10.1111/j.1744-6163.2011.00304.x. Epub 2011 Apr 13.
PURPOSE
Individuals with bulimia nervosa (BN) report altered perceptions in hunger, fullness, and satiety. This article reviews the role of cholecystokinin (CCK), a satiety-producing hormone, in the regulation of binge eating in those who suffer from BN.
CONCLUSION
Studies have shown that CCK is decreased in individuals with BN when compared with healthy controls. Decreased CCK functioning may contribute to impaired satiety and thus binge eating in this patient population. Depending on the macronutrient composition of food choices, CCK release can be differentially influenced. For instance, protein is a potent stimulator of a CCK response. Eating more protein-rich meals increases the release of CCK, increasing satiety and ending a meal.
PRACTICE IMPLICATIONS
Knowledge of CCK functioning and the utility of manipulating the macronutrient composition of meals may inform standard behavioral treatment strategies for those who suffer from BN.
目的
神经性贪食症（BN）患者报告称其对饥饿感、饱腹感和满足感的感知发生了改变。本文综述了胆囊收缩素（CCK）在调节 BN 患者暴食行为中的作用，CCK 是一种产生饱腹感的激素。
结论
与健康对照组相比，BN 患者的 CCK 水平降低。CCK 功能下降可能导致该患者群体饱腹感受损，从而导致暴食。根据食物选择的宏量营养素组成，CCK 的释放会受到不同的影响。例如，蛋白质是 CCK 反应的有效刺激物。进食更多富含蛋白质的膳食会增加 CCK 的释放，从而增加饱腹感并结束进食。
实践意义
了解 CCK 的功能以及操纵膳食宏量营养素组成的效果，可能为 BN 患者的标准行为治疗策略提供信息。
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