French S J, Murray B, Rumsey R D, Sepple C P, Read N W
Centre for Human Nutrition, University of Sheffield, Northern General Hospital, U.K.
Appetite. 1993 Oct;21(2):95-104. doi: 10.1016/0195-6663(93)90002-2.
This study was designed to test the putative role of plasma cholecystokinin (CCK) in eating behaviour by examining the relationships between bioassayed plasma CCK concentrations and rated sensations of satiety and hunger following the ingestion of an appetizing nutrient-dense meal and between plasma profiles of CCK and scintigraphically determined gastric emptying in nine healthy male volunteers. Mean plasma CCK levels from the whole group showed a significant negative correlation with mean hunger ratings (r = -0.64) and a positive correlation with fullness (r = +0.68). However, there was considerable interindividual variation and negative correlations with hunger were only seen in three out of nine subjects and positive correlations with fullness in four out of nine subjects. In contrast, there was a strong relationship between the plasma CCK produced over the first 2 h after the meal and the half time for gastric emptying of the meal (r = -0.81). These data do not support a direct role for circulating levels of CCK in the control of hunger and satiety following a meal. Instead, the strong correlation with gastric emptying is compatible with release of CCK in response to nutrient delivery into the small intestine.
本研究旨在通过检测9名健康男性志愿者摄入一顿开胃的营养丰富餐食后，生物测定的血浆胆囊收缩素（CCK）浓度与饱腹感和饥饿感评分之间的关系，以及CCK的血浆水平与闪烁扫描测定的胃排空之间的关系，来测试血浆CCK在进食行为中的假定作用。整个组的平均血浆CCK水平与平均饥饿评分呈显著负相关（r = -0.64），与饱腹感呈正相关（r = +0.68）。然而，个体间存在相当大的差异，9名受试者中只有3名出现与饥饿的负相关，9名受试者中只有4名出现与饱腹感的正相关。相比之下，餐后最初2小时内产生的血浆CCK与餐食胃排空的半衰期之间存在很强的关系（r = -0.81）。这些数据不支持循环中的CCK水平在餐后饥饿和饱腹感控制中起直接作用。相反，与胃排空的强相关性与CCK对营养物质进入小肠的反应性释放是一致的。
