Department of Clinical and Biological Sciences, University of Turin, Italy.
Curr Pharm Des. 2011 Dec 1;17(36):3994-4006. doi: 10.2174/138161211798764906.
The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.
细胞生物化学和功能的分子通讯这一复杂系统涉及许多组成部分，包括激酶、磷酸酶和转录因子，这些都已知对细胞和组织的氧化还原变化敏感。活性氧（ROS）在细胞和组织中持续生成，在促氧化剂条件下会被放大，现在被一致认为是细胞信号转导的重要触发和调节剂，因此也是细胞行为的重要触发和调节剂。这篇综述考虑了介导 ROS 反应基因调控的主要信号通路。
