基底细胞癌和鳞状细胞皮肤癌与吸烟相关癌症之间的关系。

The relationship between basal and squamous cell skin cancer and smoking related cancers.

作者信息

Sitas Freddy, Yu Xue Qin, O'Connell Dianne L, Blizzard Leigh, Otahal Petr, Newman Leah, Venn Alison

机构信息

Cancer Research Division, Cancer Council New South Wales, Sydney, Australia.

出版信息

BMC Res Notes. 2011 Dec 22;4:556. doi: 10.1186/1756-0500-4-556.

DOI:10.1186/1756-0500-4-556

PMID:22188818

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3285702/

Abstract

BACKGROUND

We compared the risk of being diagnosed with smoking-related cancers (lung, oral cavity, upper digestive and respiratory organs, bladder, kidney, anogenital cancers and myeloid leukaemia) among people with squamous cell carcinoma (SCC) or basal cell carcinoma of the skin (BCC), with risks found in the general population using data from an Australian population-based cancer registry.

METHODS

People diagnosed with BCC or SCC in 1980-2003 reported to the Tasmanian Cancer Registry, Australia, were followed-up by linkage within the registry, until diagnosis of a subsequent smoking-related cancer, death, or until 31 December 2003. Risk of developing a future smoking-related cancer was assessed using age Standardised Incidence Ratios (SIR).

RESULTS

People diagnosed with SCC had an increased risk of lung cancer (men: SIR = 1.89, 95% confidence interval: 1.61-2.21; women: SIR = 2.04, 1.42-2.83) and all other smoking-related cancers (men: SIR = 1.38, 1.19-1.60; women: SIR = 1.78, 1.34-2.33). Men with BCC had a significant increased risk of lung cancer (SIR = 1.26, 1.10-1.44) but not of any of the other smoking-related cancers (SIR = 1.09, 0.97-1.23).

CONCLUSIONS

Individuals with a history of SCC having an increased risk of developing smoking related cancers cancer suggests smoking as a common etiology. The relationship between BCC and smoking-related cancers is less certain.

摘要

背景

我们利用澳大利亚基于人群的癌症登记处的数据，比较了患有皮肤鳞状细胞癌（SCC）或基底细胞癌（BCC）的人群被诊断出患吸烟相关癌症（肺癌、口腔癌、上消化道和呼吸道器官癌、膀胱癌、肾癌、肛门生殖器癌和髓系白血病）的风险与普通人群中的风险。

方法

1980年至2003年向澳大利亚塔斯马尼亚癌症登记处报告的被诊断为BCC或SCC的人群，通过登记处内的关联进行随访，直至诊断出后续的吸烟相关癌症、死亡或直至2003年12月31日。使用年龄标准化发病率（SIR）评估未来患吸烟相关癌症的风险。

结果

被诊断为SCC的人群患肺癌的风险增加（男性：SIR = 1.89，95%置信区间：1.61 - 2.21；女性：SIR = 2.04，1.42 - 2.83）以及所有其他吸烟相关癌症（男性：SIR = 1.38，1.19 - 1.60；女性：SIR = 1.78，1.34 - 2.33）。患有BCC的男性患肺癌的风险显著增加（SIR = 1.26，1.10 - 1.44），但其他任何吸烟相关癌症的风险未增加（SIR = 1.09，0.97 - 1.23）。