Petrov V V, Arabidze G G, Levitskiĭ D O, Eliseev A O, Grishenkov E A, Kaĭkov M I, Khalilov I E
Ter Arkh. 1990;62(6):124-9.
The rate of Na-Li countertransport was studied in inpatients with essential hypertension (n = 59), chronic diffuse glomerulonephritis (n = 30), chronic pyelonephritis (n = 26), renovascular hypertension (n = 15) and in those with associated renovascular hypertension and essential hypertension (n = 4). Multiple regression analysis has demonstrated that age, body weight and blood plasma lipids do not make any significant contribution to dispersion of the counter transport rate. The mean rate of countertransport in patients with essential hypertension turned out much higher than that in patients with secondary hypertensions. Repeated examinations have shown that in every man, the countertransport rate remains unchanged for 1.5 yr. It is not affected either by hypotensive therapy or surgical treatment. In inpatients with secondary hypertension and low rates of countertransport, high arterial pressure (AP) drops after surgical treatment of the kidneys, renal vessels or adrenals. Surgical treatment of patients with secondary hypertension and high rates of countertransport does not lead to any material decrease of AP. It is assumed that the rate of Na-Li countertransport can be used for diagnosing associated secondary hypertensions and essential hypertension and prediction of AP lowering after surgical treatment.
对原发性高血压患者(n = 59)、慢性弥漫性肾小球肾炎患者(n = 30)、慢性肾盂肾炎患者(n = 26)、肾血管性高血压患者(n = 15)以及合并肾血管性高血压和原发性高血压的患者(n = 4)的钠 - 锂逆向转运速率进行了研究。多元回归分析表明,年龄、体重和血脂对逆向转运速率的离散度无显著影响。原发性高血压患者的平均逆向转运速率远高于继发性高血压患者。重复检查显示,每名男性的逆向转运速率在1.5年内保持不变。它不受降压治疗或手术治疗的影响。在继发性高血压且逆向转运速率较低的住院患者中,对肾脏、肾血管或肾上腺进行手术治疗后,动脉压(AP)会下降。对继发性高血压且逆向转运速率较高的患者进行手术治疗不会导致AP显著降低。据推测,钠 - 锂逆向转运速率可用于诊断合并的继发性高血压和原发性高血压,并预测手术治疗后AP的降低情况。