Pérez-Molina José A, Rodríguez-Guardado Azucena, Soriano Antonio, Pinazo María-Jesús, Carrilero Bartolomé, García-Rodríguez Magdalena, Salas Joaquín, Torrús Diego, Soler-Ferrer Cristina, Puente Sabino, Haro-González Juan Luís, Martín-Rabadán Pablo, Gascon Joaquim
Medicina Tropical, Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
HIV Clin Trials. 2011 Nov-Dec;12(6):287-98. doi: 10.1310/hct1206-287.
As a result of population migration, Chagas disease is no longer limited to the North and South American continents. In HIV-infected patients, chronic infection by Trypanosoma cruzi behaves as an opportunistic infection in severely immunosuppressed patients and is responsible for high morbidity and mortality. Unlike other opportunistic infections, information on the natural history, diagnosis, treatment, and prevention of Chagas disease is scarce. Spain has the highest number of cases of Chagas disease outside the North and South American continents, and coinfection with HIV is increasingly prevalent. In this article, the Spanish Society for Tropical Medicine and International Health (Sociedad Española de Medicina Tropical y Salud Internacional) reviews the current situation of coinfection with HIV and T. cruzi infection and provides guidelines on the diagnosis, treatment, and prevention in areas where Chagas disease is not endemic. It also identifies areas of uncertainty where additional research is necessary.
由于人口迁移，恰加斯病不再局限于南北美洲大陆。在艾滋病毒感染患者中，克氏锥虫慢性感染在严重免疫抑制患者中表现为机会性感染，并导致高发病率和死亡率。与其他机会性感染不同，关于恰加斯病自然史、诊断、治疗和预防的信息很少。西班牙是南北美洲大陆以外恰加斯病病例数最多的国家，且艾滋病毒合并感染日益普遍。在本文中，西班牙热带医学和国际卫生协会回顾了艾滋病毒与克氏锥虫合并感染的现状，并提供了在恰加斯病非流行地区的诊断、治疗和预防指南。它还确定了需要进一步研究的不确定领域。
