Klinik für Strahlenheilkunde, Uniklinik Freiburg, Freiburg, Germany.
Strahlenther Onkol. 2011 Dec;187(12):820-5. doi: 10.1007/s00066-011-2267-x. Epub 2011 Nov 29.
Rotational IMRT is a new technique, whose value still has to be assessed. We evaluated its adequacy for the treatment of head and neck (H&N) cancer compared to the well-established step-and-shoot IMRT.
A total of 15 patients, who were treated with either IMRT (13 patients) or VMAT (2 patients) in the H&N region, were chosen. For each patient, a treatment plan with the respective other technique was calculated. To compare the resulting dose distributions, the dose-volume histograms (DVHs) were evaluated. To quantify the differences, a new quality index (QI) was introduced, as a measure of the planning target volume (PTV) coverage and homogeneity. A conformity function (CF) was defined to estimate normal tissue sparing.
The QI for VMAT amounts to 36.3, whereas for IMRT the mean value is 66.5, indicating better PTV coverage as well as less overdosage for the rotational technique. While the sparing of organs at risk (OAR) was similar for both techniques, the CF shows a significantly better sparing of healthy tissue for all doses with VMAT treatment.
VMAT results in dose distributions for H&N patients that are at least comparable with treatments performed with step-and-shoot IMRT. Two new tools to quantify the quality of dose distributions are presented and have proven to be useful.
旋转调强放疗(Rotational IMRT)是一种新技术,其价值仍有待评估。我们评估了其对头颈部(H&N)癌症治疗的适用性,与成熟的分步调强放疗(step-and-shoot IMRT)进行了比较。
选择了在 H&N 区域接受调强放疗(IMRT)(13 例)或容积旋转调强放疗(VMAT)(2 例)治疗的 15 例患者。为每位患者计算了各自其他技术的治疗计划。为了比较得到的剂量分布,评估了剂量体积直方图(DVHs)。为了量化差异,引入了一个新的质量指数(QI),作为计划靶区(PTV)覆盖和均匀性的度量。定义了一个适形函数(CF)来估计正常组织的保护。
VMAT 的 QI 值为 36.3,而 IMRT 的平均值为 66.5,这表明旋转技术的 PTV 覆盖更好,同时剂量过高的情况也更少。虽然两种技术的危及器官(OAR)保护相似,但 CF 显示 VMAT 治疗的所有剂量下健康组织的保护明显更好。
VMAT 为 H&N 患者提供的剂量分布至少与分步调强放疗相当。提出了两种新的工具来量化剂量分布的质量,并且已经证明是有用的。