Elser Denise M, Mitchell Gretchen K, Miklos John R, Nickell Kevin G, Cline Kevin, Winkler Harvey, Wells W Glen
Illinois Urogynecology, LTD., 5716 West 95th Street, Oak Lawn, IL 60453-2345, USA.
Adv Urol. 2011;2011:872057. doi: 10.1155/2011/872057. Epub 2011 Dec 5.
Objective. To assess treatment efficacy and quality of life in women with stress urinary incontinence 3 years after treatment with nonsurgical transurethral radiofrequency collagen denaturation. Methods. This prospective study included 139 women with stress urinary incontinence due to bladder outlet hypermobility. Radiofrequency collagen denaturation was performed using local anesthesia in an office setting. Assessments included incontinence quality of life (I-QOL) and urogenital distress inventory (UDI-6) instruments. Results. In total, 139 women were enrolled and 136 women were treated (mean age, 47 years). At 36 months, intent-to-treat analysis (n = 139) revealed significant improvements in quality of life. Mean I-QOL score improved 17 points from baseline (P = .0004), while mean UDI-6 score improved (decreased) 19 points (P = .0005). Conclusions. Transurethral collagen denaturation is a low-risk, office-based procedure that results in durable quality-of-life improvements in a significant proportion of women for as long as 3 years.
目的。评估非手术经尿道射频胶原变性治疗3年后压力性尿失禁女性的治疗效果和生活质量。方法。这项前瞻性研究纳入了139例因膀胱出口活动过度导致压力性尿失禁的女性。在门诊环境中使用局部麻醉进行射频胶原变性治疗。评估包括尿失禁生活质量（I-QOL）和泌尿生殖系统困扰量表（UDI-6）。结果。总共纳入了139例女性，136例接受了治疗（平均年龄47岁）。在36个月时，意向性分析（n = 139）显示生活质量有显著改善。I-QOL平均得分较基线提高了17分（P = .0004）；而UDI-6平均得分提高（降低）了19分（P = .0005）。结论。经尿道胶原变性是一种低风险的门诊手术，在相当比例的女性中可持久改善生活质量，长达3年。
