Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Clin Microbiol Infect. 2012 Feb;18(2):E34-6. doi: 10.1111/j.1469-0691.2011.03726.x. Epub 2011 Dec 22.
Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase bla(NDM) gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the bla(NDM-2) gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the bla(NDM-2) gene showed significant similarities with those associated with bla(NDM-1) in Enterobacteriaceae and A. baumannii. Repeated isolation of bla(NDM-2)-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.
在阿布扎比医院分离的 155 株耐碳青霉烯类鲍曼不动杆菌中,筛查出两株携带金属β-内酰胺酶 bla(NDM)基因的菌株。这两株菌相隔 4 个月从一位曾在埃及、黎巴嫩和阿拉伯联合酋长国接受治疗的癌症患者的尿液中分离出来。它们具有克隆相关性,携带 bla(NDM-2)基因,该基因最近在埃及和以色列的鲍曼不动杆菌中被发现。bla(NDM-2)基因周围的序列与肠杆菌科和鲍曼不动杆菌中 bla(NDM-1)相关序列具有显著相似性。bla(NDM-2)阳性鲍曼不动杆菌在中东地区的反复分离,提示了一种独特克隆的本地出现和传播的可能性。