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阿联酋产 NDM-2 碳青霉烯酶鲍曼不动杆菌。

NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates.

机构信息

Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

出版信息

Clin Microbiol Infect. 2012 Feb;18(2):E34-6. doi: 10.1111/j.1469-0691.2011.03726.x. Epub 2011 Dec 22.

Abstract

Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase bla(NDM) gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the bla(NDM-2) gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the bla(NDM-2) gene showed significant similarities with those associated with bla(NDM-1) in Enterobacteriaceae and A. baumannii. Repeated isolation of bla(NDM-2)-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.

摘要

在阿布扎比医院分离的 155 株耐碳青霉烯类鲍曼不动杆菌中,筛查出两株携带金属β-内酰胺酶 bla(NDM)基因的菌株。这两株菌相隔 4 个月从一位曾在埃及、黎巴嫩和阿拉伯联合酋长国接受治疗的癌症患者的尿液中分离出来。它们具有克隆相关性,携带 bla(NDM-2)基因,该基因最近在埃及和以色列的鲍曼不动杆菌中被发现。bla(NDM-2)基因周围的序列与肠杆菌科和鲍曼不动杆菌中 bla(NDM-1)相关序列具有显著相似性。bla(NDM-2)阳性鲍曼不动杆菌在中东地区的反复分离,提示了一种独特克隆的本地出现和传播的可能性。

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