吗啡对成年和老年大鼠热敏感性的影响。
Effects of morphine on thermal sensitivity in adult and aged rats.
机构信息
Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32610, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):705-13. doi: 10.1093/gerona/glr210. Epub 2011 Dec 21.
Abstract
There are contradictory data regarding older individuals' sensitivity to pain stimulation and opioid administration. Adult (12-16 months; n = 10) and aged (27-31 months; n = 7) male F344xBN rats were tested in a thermal sensitivity procedure where the animal chooses to remain in one of two compartments with floors maintained at various temperatures ranging from hot (45°C) through neutral (30°C) to cold (15°C). Effects of morphine were determined for three temperature comparisons (ie, hot/neutral, cold/neutral, and hot/cold). Aged rats were more sensitive to cold stimulation during baseline. Morphine produced antinociception during hot thermal stimulation, but had no effect on cold stimulation. The antinociceptive (and locomotor-altering) effects of morphine were attenuated in aged rats. These data demonstrate age-related differences in baseline thermal sensitivity and responsiveness to opioids. Based on behavioral and physiological requirements of this procedure, it is suggested that thermal sensitivity may provide a relevant animal model for the assessment of pain and antinociception.
摘要
关于老年人对疼痛刺激和阿片类药物给药的敏感性存在相互矛盾的数据。在热敏感性程序中对成年（12-16 个月；n = 10）和老年（27-31 个月；n = 7）雄性 F344xBN 大鼠进行了测试，动物选择留在地板保持在不同温度范围从热（45°C）通过中性（30°C）到冷（15°C）的两个隔间之一。确定了吗啡对三种温度比较的影响（即，热/中性、冷/中性和热/冷）。在基线期，老年大鼠对冷刺激更敏感。吗啡在热刺激时产生镇痛作用，但对冷刺激没有影响。吗啡的镇痛（和运动改变）作用在老年大鼠中减弱。这些数据表明，基线热敏感性和对阿片类药物的反应存在与年龄相关的差异。根据该程序的行为和生理要求，建议热敏感性可能为疼痛和镇痛评估提供相关的动物模型。
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