Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
J Chromatogr A. 2012 Jan 13;1220:82-91. doi: 10.1016/j.chroma.2011.11.059. Epub 2011 Dec 7.
Barium-137m availed from a (137)Cs/(137m)Ba generator is an attractive industrial radiotracer for liquid flow rate measurement owing to its short half-life (T(1/2)=2.5 min) and emission of highly energetic gamma radiation (E(γ)=661.7 keV). Ammonium molybdophosphate (AMP) impregnated alumina microspheres (AMP-Al(2)O(3)), an engineered form of sorbent material was synthesized by Gel Entrapment Technique (GET). The utility of the material in the preparation of (137)Cs/(137m)Ba generator was evaluated. Various experimental parameters were optimized for efficient retention of (137)Cs and selective elution of (137m)Ba. A chromatographic 0.74 GBq (20 mCi) (137)Cs/(137m)Ba generator was developed using this material and its performance was evaluated for 6 months. Barium-137m could be eluted from the generator using 0.1 M NH(4)NO(3)+0.5 M HNO(3) solution with >80% yield and with acceptable radionuclidic purity suitable for industrial radiotracer investigations.
从 (137)Cs/(137m)Ba 发生器获得的钡-137m 由于其半衰期短（T(1/2)=2.5 分钟）和发射高能伽马辐射（E(γ)=661.7 keV），是一种有吸引力的工业放射性示踪剂，可用于测量液体流速。磷酸钼铵（AMP）浸渍氧化铝微球（AMP-Al(2)O(3)）是一种通过凝胶包埋技术（GET）合成的吸附材料的工程形式。评估了该材料在制备 (137)Cs/(137m)Ba 发生器中的应用。优化了各种实验参数，以有效保留 (137)Cs 和选择性洗脱 (137m)Ba。使用这种材料开发了一种放射性活度为 0.74 GBq（20 mCi）的 (137)Cs/(137m)Ba 发生器，并对其性能进行了 6 个月的评估。钡-137m 可以使用 0.1 M NH(4)NO(3)+0.5 M HNO(3)溶液以>80%的产率和可接受的放射性核纯度从发生器中洗脱出来，适用于工业放射性示踪剂研究。
