Christiana Care Health System, Newark, DE 19718, USA.
J Card Fail. 2012 Jan;18(1):21-7. doi: 10.1016/j.cardfail.2011.09.004. Epub 2011 Oct 19.
Peripartum cardiomyopathy (PPCM) mortality rates vary between 2% and 56%, with half occurring ≤12 weeks'; postpartum. Although risk factors for PPCM have been identified, predicting sudden cardiac death among PPCM patients remains difficult. This study describes the characteristics and outcomes of PPCM patients and controls referred for a wearable cardioverter defibrillator (WCD).
Deidentified WCD medical orders between 2003 and 2009 and death index searches were used to characterize women (ages 17-43) with PPCM (n = 107) or matched nonpregnant women with nonischemic dilated cardiomyopathy (NIDCM; n = 159). Demographics were similar. WCD use averaged 124 ± 123 days and 96 ± 83 days among PPCM and NIDCM patients, respectively. No PPCM patients received an appropriate shock for ventricular tachycardia/ventricular fibrillation; 1 NIDCM patient received 2 successful shocks. No PPCM patient died during WCD use versus 11 concurrent NIDCM deaths. After WCD use, 3 PPCM and 13 NIDCM patients died, respectively.
The mortality rate of 2.8% (over 3.0 ± 1.2 years) in PPCM patients is low compared to published data. The role of WCD therapy among PPCM patients deserves further study.
围产期心肌病（PPCM）的死亡率在 2%至 56%之间，其中一半发生在产后 12 周内。虽然已经确定了 PPCM 的危险因素，但预测 PPCM 患者的心脏性猝死仍然很困难。本研究描述了接受植入式心律转复除颤器（ICD）的 PPCM 患者和对照患者的特征和结局。
使用 2003 年至 2009 年期间的 ICD 医疗医嘱和死亡索引搜索来描述患有 PPCM（n=107）或匹配的非妊娠、非缺血性扩张型心肌病（NIDCM；n=159）的女性（年龄 17-43 岁）的特征。两组患者的人口统计学特征相似。PPCM 患者的 ICD 使用平均为 124±123 天，NIDCM 患者为 96±83 天。没有 PPCM 患者因室性心动过速/心室颤动接受过合适的电击治疗；1 例 NIDCM 患者接受了 2 次成功的电击治疗。在 ICD 使用期间，没有 PPCM 患者死亡，而同期有 11 例 NIDCM 患者死亡。在 ICD 使用后，分别有 3 例 PPCM 和 13 例 NIDCM 患者死亡。
与已发表的数据相比，PPCM 患者的死亡率为 2.8%（3.0±1.2 年），相对较低。PPCM 患者的 ICD 治疗作用值得进一步研究。
