Soloff M S, Alexandrova M, Fernstrom M J
Science. 1979 Jun 22;204(4399):1313-5. doi: 10.1126/science.221972.
Specific binding of tritiated oxytocin to uterine receptors of pregnant rats increases dramatically at term and is maximal during labor. In mammary glands the increase in binding is gradual, reaching a maximum during the lactation period. Concomitant changes in the sensitivity of the uterus and mammary gland to oxytocin indicate that the receptor concentration is of functional significance. Oxytocin receptors, therefore, may regulate the response of the target organs to circulating oxytocin and thereby control the onset of labor and lactation. Ovarian steroids participate in the regulation of oxytocin receptors in a manner as yet unclarified.
氚标记的催产素与妊娠大鼠子宫受体的特异性结合在足月时急剧增加，并在分娩期间达到最大值。在乳腺中，结合的增加是渐进的，在哺乳期达到最大值。子宫和乳腺对催产素敏感性的伴随变化表明受体浓度具有功能意义。因此，催产素受体可能调节靶器官对循环催产素的反应，从而控制分娩和泌乳的开始。卵巢类固醇以一种尚不清楚的方式参与催产素受体的调节。
