Salgado-Martínez Yomira, González-Rodríguez Magali, Villanueva-Arriaga Rosina Eugenia, Molina-Frechero Nelly
Universidad Autónoma Metropolitana, Unidad Xochimilco, División de Ciencias Biológicas y de la Salud, Maestría en Ciencias Odontológicas. Ciudad de México, México.
Universidad Autónoma Metropolitana, Unidad Xochimilco, División de Ciencias Biológicas y de la Salud, Coordinación de la Maestría en Ciencias Odontológicas. Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2025 Jan 3;63(1):e5592. doi: 10.5281/zenodo.14200998.
An imbalance between the plaque biofilm and the host's immune system results in the overexpression of several proinflammatory interleukins, the spread of inflammation through the gums leading to the destruction of connective tissue and the subsequent destruction of the gingival tissue. Periodontal diseases are among the most common diseases, since they affect up to 50% of the world population. Often, the lower socioeconomic groups are the most affected, as well as the elderly. Interleukins play a fundamental role in the immune response and they are secreted by various cells, such as macrophages, mast cells, lymphocytes, etcetera. Due to the above, the objective was to carry out a systematic review of articles that relate interleukins and bone degeneration in periodontal disease, and this review was carried out in 4 databases: Scopus, PubMed, SciELO and Springerlink, using the keywords: Proflammatory interleukin and Periodontal disease, applying the following search strategy: IT ((interleukin) AND (periodontal disease or periodontitis) AND (bone)). The search gave a result of 12 scientific articles that corresponded to the topic, and obtained a good evaluation regarding the bias and quality of the article. We concluded that periodontal disease is complex and interleukins have been shown to establish a multidirectional link for the development of this disease.
菌斑生物膜与宿主免疫系统之间的失衡会导致多种促炎白细胞介素的过度表达，炎症通过牙龈扩散，导致结缔组织破坏，进而导致牙龈组织破坏。牙周疾病是最常见的疾病之一，因为它们影响着全球多达50%的人口。通常，社会经济地位较低的群体以及老年人受影响最大。白细胞介素在免疫反应中起重要作用，它们由各种细胞分泌，如巨噬细胞、肥大细胞、淋巴细胞等。基于上述情况，目的是对与牙周疾病中白细胞介素和骨质退化相关的文章进行系统综述，该综述在4个数据库中进行：Scopus、PubMed、SciELO和Springerlink，使用关键词：促炎白细胞介素和牙周疾病，应用以下搜索策略：IT（（白细胞介素）AND（牙周疾病或牙周炎）AND（骨））。搜索结果得到了12篇与该主题相关的科学文章，并在文章的偏倚和质量方面获得了良好评价。我们得出结论，牙周疾病很复杂，并且白细胞介素已被证明为该疾病的发展建立了多方向联系。
