MEG Center, University Tübingen, Germany.
Neuroimage. 2012 Mar;60(1):362-9. doi: 10.1016/j.neuroimage.2011.12.012. Epub 2011 Dec 16.
There is growing evidence that excessive body weight correlates with impaired cognitive performance like executive function, attention and memory. In our study, we applied a visual working memory task to quantify associations between body weight and executive function. In total, 34 lean (BMI 22±2.1 kg/m(2)) and 34 obese (BMI 30.4±3.2 kg/m(2)) subjects were included. Magnetic brain activity and behavioral responses were recorded during a one-back visual memory task with food and non-food pictures, which were matched for color, size and complexity. Behavioral responses (reaction time and accuracy) were reduced in obese subjects independent of the stimulus category. Neuronal activity at the source level showed a positive correlation between the right dorsolateral prefrontal cortex (DLPFC) activity and BMI only for the food category. In addition, a negative correlation between BMI and neuronal activity was observed in the occipital area for both categories. Therefore we conclude that increased body weight is associated with reduced task performance and specific neuronal changes. This altered activity is probably related to executive function as well as encoding and retrieval of information.
越来越多的证据表明，体重过高与执行功能、注意力和记忆力等认知表现受损有关。在我们的研究中，我们应用视觉工作记忆任务来量化体重与执行功能之间的关联。共有 34 名瘦体重者（BMI 22±2.1kg/m²）和 34 名肥胖者（BMI 30.4±3.2kg/m²）参与了研究。在一项包含食物和非食物图片的 1 -back 视觉记忆任务中，记录了参与者的大脑磁活动和行为反应，这些图片在颜色、大小和复杂度上是匹配的。无论刺激类别如何，肥胖者的行为反应（反应时间和准确性）都有所降低。在源水平上的神经活动显示，右侧背外侧前额叶皮层（DLPFC）的活动与 BMI 仅在食物类别中呈正相关。此外，对于两种类别，在枕叶区域观察到 BMI 与神经元活动之间呈负相关。因此，我们得出结论，体重增加与任务表现下降和特定的神经元变化有关。这种改变的活动可能与执行功能以及信息的编码和检索有关。
