fMEG Center, University Tübingen, Germany; Institute of Medical Psychology and Behavioral Neurosciences, University of Tübingen, Germany; Graduate School of Neural and Behavioral Sciences, International Max Planck Research School, University Tübingen, Germany.
Obesity (Silver Spring). 2013 Dec;21(12):2488-94. doi: 10.1002/oby.20442. Epub 2013 Jul 2.
Lifestyle interventions including reduction of caloric intake are still the most pursued option to treat obesity. However, their outcome in terms of weight loss strongly differs between participants. In our study, we hypothesized that initial differences in brain activation in a food specific memory task are associated with weight change during a lifestyle intervention.
Magnetic brain activity was recorded during a one-back visual memory task with food and nonfood pictures in 33 overweight and obese subjects before they underwent a lifestyle intervention. The intervention lasted 6 months and aimed for a reduction in daily caloric intake by 400 kcal. Body mass index (BMI) was determined before and after the intervention.
Differences between outer tertiles representing people who increased their BMI by 1.4% ± 1.1% (non-responders) and who reduced their BMI by -6.9% ± 2.6% (responders) are reported. Neuronal activity was related to BMI change in sensor and source space. Non-responders showed higher activation in right inferior frontal and left occipital visual areas, whereas responders showed increased activation in right temporal areas including hippocampus and fusiform gyrus.
Differences in the cerebral response during a food specific memory task indicate an altered cognitive control over food intake. These differences might determine the ability to eat less and successfully lose weight.
包括减少热量摄入在内的生活方式干预仍然是治疗肥胖的最常用方法。然而，它们在减肥方面的效果在参与者之间有很大的差异。在我们的研究中，我们假设在特定食物记忆任务中的大脑激活的初始差异与生活方式干预期间的体重变化有关。
在 33 名超重和肥胖者接受生活方式干预之前，他们进行了一项带有食物和非食物图片的 1 -back 视觉记忆任务，记录了大脑的磁场活动。干预持续 6 个月，目标是每天减少 400 卡路里的热量摄入。在干预前后测定体重指数（BMI）。
报告了代表 BMI 增加 1.4%±1.1%（无反应者）和减少 6.9%±2.6%（反应者）的外三分位数之间的差异。在传感器和源空间中，神经元活动与 BMI 变化有关。无反应者的右侧额下回和左侧枕叶视觉区域的激活较高，而反应者的右侧颞叶区域包括海马体和梭状回的激活增加。
在特定食物记忆任务中大脑反应的差异表明对食物摄入的认知控制发生了改变。这些差异可能决定了减少食物摄入量和成功减肥的能力。
