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大鼠体内五氯苯酚（PCP）的代谢研究。

Metabolic studies on pentachlorophenol (PCP) in rats.

作者信息

Renner G, Hopfer C

机构信息

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, FRG.

出版信息

Xenobiotica. 1990 Jun;20(6):573-82. doi: 10.3109/00498259009046872.

DOI:10.3109/00498259009046872
PMID:2219952
Abstract
  1. The metabolism of pentachlorophenol in rats was studied. 2. Metabolites isolated from rat urine and identified were: 2,3,4,5-tetrachlorophenol, 2,3,4,6-tetrachlorophenol, 2,3,5,6-tetrachlorophenol, tetrachlorocatechol, tetrachlororesorcinol, trichlorohydroquinone, tetrachlorohydroquinone, and traces of trichloro-1,4-benzoquinone, and tetrachloro-1,4-benzoquinone.
摘要
  1. 研究了大鼠体内五氯苯酚的代谢情况。2. 从大鼠尿液中分离并鉴定出的代谢产物有：2,3,4,5-四氯苯酚、2,3,4,6-四氯苯酚、2,3,5,6-四氯苯酚、四氯邻苯二酚、四氯间苯二酚、三氯对苯二酚、四氯对苯二酚，以及痕量的三氯-1,4-苯醌和四氯-1,4-苯醌。

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Metabolic studies on pentachlorophenol (PCP) in rats.大鼠体内五氯苯酚（PCP）的代谢研究。
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Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.五氯苯酚诱导致癌性的潜在机制：一种不依赖金属产生羟基自由基的新机制。
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Simultaneous assay of pentachlorophenol and its metabolite, tetrachlorohydroquinone, by gas chromatography without derivatization.气相色谱法同时测定五氯苯酚及其代谢物四氯对苯二酚，无需衍生化。
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引用本文的文献

1
Toxicological profile of chlorophenols and their derivatives in the environment: the public health perspective.环境中氯酚及其衍生物的毒理学概况：公共卫生视角
ScientificWorldJournal. 2013 Apr 3;2013:460215. doi: 10.1155/2013/460215. Print 2013.
2
Subchronic hepatotoxicity evaluation of 2,3,4,6-tetrachlorophenol in sprague dawley rats.2,3,4,6-四氯苯酚对斯普拉格-道利大鼠的亚慢性肝毒性评估
J Toxicol. 2012;2012:376246. doi: 10.1155/2012/376246. Epub 2012 May 15.
3
Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1.
五氯苯酚和其他氯代酚是人类羟基类固醇磺基转移酶hSULT2A1的底物。
Chem Res Toxicol. 2008 Aug;21(8):1503-8. doi: 10.1021/tx800133d. Epub 2008 Jul 26.