The metabolism of lindance and its metabolites gamma-2,3,4,5,6-pentachlorocyclohexene, pentachlorobenzene, and pentachlorophenol in rats and the pathways of lindance metabolism.

The metabolism of lindane and its metabolites, gamma-PCCH, PCB, and PCP, has been studied in rats. Urine, faeces, blood and important organs were analyzed for free metabolities and those bound as beta-glucuronides. TeCCOL was identified as a main metabolite by GC/MS and gamma-PCCH has been evaluated toxicologically. A degradation scheme, based on experimental results and comprising only one hypothetical metabolite is proposed and discussed.