Minton J P, Foecking M K, Webster D J, Matthews R H
Surgery. 1979 Jul;86(1):105-9.
Methylxanthine consumption is associated with the development of fibrocystic disease of the breast. Methylxanthine abstention is associated with resolution of signs and symptoms of fibrocystic disease. Abstinence from methylxanthine consumption decreased breast biopsies and the need for major breast surgery because of benign disease. Methylxanthine consumption is associated with elevated cyclic adenosine monophosphate (AMP) and cyclic guanosine monophosphate (GMP) values in fibrocystic dsiease over those obtained in normal breast tissue.
摄入甲基黄嘌呤与乳腺纤维囊性疾病的发生有关。戒除甲基黄嘌呤与纤维囊性疾病体征和症状的缓解有关。戒除甲基黄嘌呤摄入减少了乳腺活检以及因良性疾病进行乳房大手术的需求。与正常乳腺组织相比，纤维囊性疾病中甲基黄嘌呤的摄入与环磷酸腺苷（AMP）和环磷酸鸟苷（GMP）值升高有关。
