Tohyama Takamichi, Fujiwara Toshiyuki, Matsumoto Jun, Honaga Kaoru, Ushiba Junichi, Tsuji Tetsuya, Hase Kimitaka, Liu Meigen
Department of Rehabilitation Medicine, School of Medicine, Keio University, Tokyo, Japan.
Keio J Med. 2011;60(4):114-8. doi: 10.2302/kjm.60.114.
Recently, surface electroencephalogram (EEG)-based brain-machine interfaces (BMI) have been used for people with disabilities. As a BMI signal source, event-related desynchronization of alpha-band EEG (8-13 Hz) during motor imagery (mu ERD), which is interpreted as desynchronized activities of the activated neurons, is commonly used. However, it is often difficult for patients with severe hemiparesis to produce mu ERD of sufficient strength to activate BMI. Therefore, whether it is possible to modulate mu ERD during motor imagery with anodal transcranial direct-current stimulation (tDCS) was assessed in a severe left hemiparetic stroke patient. EEG was recorded over the primary motor cortex (M1), and mu ERD during finger flexion imagery was measured before and after a 5-day course of tDCS applied to M1. The ERD recorded over the affected M1 increased significantly after tDCS intervention. Anodal tDCS may increase motor cortex excitability and potentiate ERD during motor imagery in patients with severe hemiparetic stroke.
最近，基于表面脑电图（EEG）的脑机接口（BMI）已被应用于残疾人。作为BMI信号源，运动想象期间α波段脑电图（8 - 13赫兹）的事件相关去同步化（μ ERD），被解释为激活神经元的去同步化活动，被广泛使用。然而，严重偏瘫患者通常难以产生足够强度的μ ERD来激活BMI。因此，在一名严重左侧偏瘫中风患者中评估了是否可以通过阳极经颅直流电刺激（tDCS）在运动想象期间调节μ ERD。在初级运动皮层（M1）记录脑电图，并在对M1进行为期5天的tDCS疗程前后测量手指屈曲想象期间的μ ERD。tDCS干预后，在受影响的M1上记录到的ERD显著增加。阳极tDCS可能会增加严重偏瘫中风患者运动想象期间的运动皮层兴奋性并增强ERD。
