Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati OH 45229, USA.
Pediatrics. 2012 Jan;129(1):e195-8. doi: 10.1542/peds.2011-0217. Epub 2011 Dec 26.
A 10-year-old girl presented with diabetic ketoacidosis, shock, and severe abdominal pain. She was found to have acute pancreatitis and acute kidney injury after shock resuscitation and severe persistent hypertriglyceridemia. The severe hypertriglyceridemia was treated with 1 course of plasmapheresis, which corrected the triglyceride level and was temporally associated with improvement of the abdominal pain and renal dysfunction. Diabetes is known to contribute to an elevated triglyceride level, especially in the setting of an underlying lipid disorder. However, no such disorders were found in this patient. To the best of our knowledge, this is the first report of a pediatric patient presenting with the triad of severe hypertriglyceridemia, diabetic ketoacidosis, and pancreatitis treated successfully with plasmapheresis.
一位 10 岁女孩因糖尿病酮症酸中毒、休克和严重腹痛就诊。在休克复苏和严重持续性高甘油三酯血症后，发现她患有急性胰腺炎和急性肾损伤。严重的高甘油三酯血症经过 1 个疗程的血浆置换治疗，纠正了甘油三酯水平，并暂时改善了腹痛和肾功能障碍。众所周知，糖尿病会导致甘油三酯水平升高，尤其是在存在潜在脂质紊乱的情况下。然而，在这名患者中并未发现此类疾病。据我们所知，这是首例报道的儿科患者成功接受血浆置换治疗严重高甘油三酯血症、糖尿病酮症酸中毒和胰腺炎三联征的病例。
