Suppr超能文献

在环意大利自行车赛 3 周赛段期间,不同公式评估职业自行车手的肌酐、胱抑素 C 和 eGFR。

Evaluation of creatinine, cystatin C and eGFR by different equations in professional cyclists during the Giro d'Italia 3-weeks stage race.

机构信息

I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy.

出版信息

Scand J Clin Lab Invest. 2012 Apr;72(2):114-20. doi: 10.3109/00365513.2011.642305. Epub 2011 Dec 27.

Abstract

Abstract In this study, creatinine-based equations to evaluate glomerular filtration rate (eGFR) were proposed to more accurately assess kidney function, and cystatin C, a parameter not dependent on muscular mass, was introduced to improve GFR calculation in professional cyclists during a long-lasting race. Nine cyclists participating in the 2011 Giro d'Italia were recruited. Blood and anthropometrical data were collected the day before (T-1) the race, on the 12th day (T 12) and on the 22nd day (T 22) of the race. Haemoglobin and haematocrit were registered. Haemodilution was observed at T 12, whilst stabilization was evident at T 22. Creatinine, cystatin C concentrations and eGFR values were not modified during the observed period; only GFR evaluated with the Cockcroft-Gault (CG) formula and expressed as ml/min/1.73 m(2) significantly decreased (p < 0.05) at T 22 in comparison with T-1, probably as a consequence of weight decrease. Cystatin C levels were in the reference range, while creatinine concentrations were lower. The lowest eGFR values were observed with CG normalized and the Modification of Diet in Renal Disease (MDRD) formulas. A good correlation was observed between the MDRD and the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations and between CG normalized and both CKD-EPI and MDRD formulas. The worst correlation was registered between CKD-EPI creatinine and cystatin C and all the other equations. In conclusion, adaptive mechanisms of renal function allow athletes to maintain stable creatinine, cystatin C and eGFR values during a long-lasting race. The use of GFR equations to evaluate general health status of sportsmen should be recommended with caution, considering also weight modification during competition.

摘要

摘要 在这项研究中,提出了基于肌酐的方程来评估肾小球滤过率(eGFR),以更准确地评估肾功能,并引入胱抑素 C,一种不依赖肌肉质量的参数,以改善职业自行车运动员在长时间比赛中的 GFR 计算。招募了 9 名参加 2011 年环意大利自行车赛的自行车运动员。在比赛前一天(T-1)、第 12 天(T 12)和第 22 天(T 22)收集了血液和人体测量数据。记录了血红蛋白和血细胞比容。在 T 12 时观察到血液稀释,而在 T 22 时则明显稳定。在观察期间,肌酐、胱抑素 C 浓度和 eGFR 值没有改变;只有用 Cockcroft-Gault(CG)公式评估的 GFR 值并表示为 ml/min/1.73 m(2),在 T 22 时与 T-1 相比显著降低(p < 0.05),可能是由于体重减轻所致。胱抑素 C 水平在参考范围内,而肌酐浓度较低。CG 标准化和改良肾脏病饮食(MDRD)公式的 eGFR 值最低。MDRD 方程与慢性肾脏病-流行病学合作(CKD-EPI)方程之间以及 CG 标准化与 CKD-EPI 和 MDRD 方程之间观察到良好的相关性。CKD-EPI 肌酐和胱抑素 C 与所有其他方程之间的相关性最差。总之,肾功能的适应性机制允许运动员在长时间比赛中维持稳定的肌酐、胱抑素 C 和 eGFR 值。在评估运动员整体健康状况时,应谨慎使用 GFR 方程,同时还要考虑比赛期间的体重变化。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验