Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Cancer Imaging. 2011 Dec 28;11(1):247-52. doi: 10.1102/1470-7330.2011.0034.
Radiofrequency-assisted intact specimen biopsy (RFIB) has been introduced for percutaneous biopsy or removal of breast tumors. Using radiofrequency cutting, the system enables the radiologist to obtain an intact sample of the target lesion. According to the IDEAL recommendations, we performed a critical evaluation of our initial experience with RFIB. Between June and November 2010, radiography-guided RFIB was performed in 19 female patients. All patients presented with suspicious microcalcifications (BI-RADS III-V) on mammography. Biopsy specimen integrity, thermal damage and histologic diagnosis were assessed by an expert breast pathologist. Data on technical success, diagnostic and therapeutic accuracy and periprocedural complications were collected and analyzed. The median age of the patients was 59 years. Median lesion diameter on mammography was 8 mm (range 2-76 mm). The procedure was successful in 16/19 (84%) patients and unsuccessful in 3/19 (16%) patients (2 non-representative samples, 1 sample with extensive thermal damage). Histologic analysis of the RFIB specimen revealed 12/19 (63%) benign lesions and 7/19 (37%) malignancies (4 ductal carcinoma in situ (DCIS) lesions and 3 invasive ductal carcinomas). In 1 patient, a DCIS lesion was completely removed with RFIB. Overall, 3 periprocedural complications occurred (1 wound leakage, 1 arterial hemorrhage and 1 infection requiring oral antibiotics). Tissue sampling of suspicious breast lesions can be performed successfully with RFIB. In 1 patient DCIS was radically excised with RFIB, which illustrates its potential as a minimally invasive therapeutic procedure for removal of small breast tumors. This is an interesting focus for further research when larger probe sizes become available.
射频辅助完整标本活检（RFIB）已被引入用于经皮活检或切除乳腺肿瘤。该系统使用射频切割，使放射科医生能够获得目标病变的完整样本。根据 IDEAL 建议，我们对我们使用 RFIB 的初始经验进行了批判性评估。在 2010 年 6 月至 11 月期间，对 19 名女性患者进行了放射摄影引导下的 RFIB。所有患者在乳房 X 线照相术上均显示可疑微钙化（BI-RADS III-V）。活检标本完整性、热损伤和组织学诊断由一名专家乳腺病理学家进行评估。收集并分析了技术成功率、诊断和治疗准确性以及围手术期并发症的数据。患者的中位年龄为 59 岁。乳房 X 线照相术上的中位病变直径为 8 毫米（范围 2-76 毫米）。该程序在 16/19 例（84%）患者中成功，在 3/19 例（16%）患者中不成功（2 例非代表性样本，1 例样本热损伤广泛）。RFIB 标本的组织学分析显示 12/19 例（63%）良性病变和 7/19 例（37%）恶性病变（4 例导管原位癌（DCIS）病变和 3 例浸润性导管癌）。在 1 例患者中，DCIS 病变通过 RFIB 完全切除。总体而言，发生了 3 例围手术期并发症（1 例伤口渗漏，1 例动脉出血和 1 例需要口服抗生素的感染）。可疑乳腺病变的组织取样可以通过 RFIB 成功进行。在 1 例患者中，RFIB 根治性切除了 DCIS，这说明了其作为一种微创治疗方法切除小的乳腺肿瘤的潜力。当可用更大的探头尺寸时，这是进一步研究的一个有趣重点。
