Kumar Balvinder, Manuja Anju, Aich Palok
National Research Centre on Equines, Hisar (Haryana) 125001, India.
Front Biosci (Elite Ed). 2012 Jan 1;4(5):1759-67. doi: 10.2741/e496.
This article presents a brief overview of stress and its impact on growth, production, reproduction and disease susceptibility in farm animals. A single measure of stress might not be a reliable indicator and it is usually more informative to combine multiple indicators of stress to assess animal welfare. Popular measures of stress such as alterations in hormonal profiles can be complemented with behavioral and immunological changes. Traditional approaches are insufficient to unravel the role of large number of genes and interconnected genetic pathways leading to multiple responses to stresses. Modern genomic and proteomics methodologies used in identifying the biomarkers and molecular mechanisms of stress response have also been described briefly. With a better understanding of the basic biology, altered physiological processes and the genes/proteins involved in stress adaptability, it would be possible to develop methodologies for selection of animals with better performance and devise strategies for animal welfare.
本文简要概述了应激及其对农场动物生长、生产、繁殖和疾病易感性的影响。单一的应激指标可能不是可靠的指标,通常将多个应激指标结合起来评估动物福利会更具信息价值。诸如激素谱变化等常见的应激指标可以通过行为和免疫变化来补充。传统方法不足以揭示导致对压力产生多种反应的大量基因和相互关联的遗传途径的作用。本文还简要介绍了用于识别应激反应生物标志物和分子机制的现代基因组学和蛋白质组学方法。通过更好地理解基础生物学、改变的生理过程以及参与应激适应性的基因/蛋白质,将有可能开发出选择性能更好的动物的方法,并制定动物福利策略。